Karl-Heinz Wiesmueller

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Introduction: Crossing the plasma membrane is a prerequisite for intracellular targeted drug delivery. Cell penetrating peptides (CPPs) are known to transport cargo molecules attached to it into cells primarily by endocytosis. Nevertheless, confinement of biomolecules into endosomes limits their use for intracellular targeting. We developed a novel(More)
BACKGROUND Class II MHC molecules (MHC II) are cell surface receptors displaying short protein fragments for the surveillance by CD4+ T cells. Antigens therefore have to be loaded onto this receptor in order to induce productive immune responses. On the cell surface, most MHC II molecules are either occupied by ligands or their binding cleft has been(More)
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