Karl‐Heinz Hiller

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BACKGROUND Sphingosine-1-phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia-reperfusion injury, and ischemic preconditioning. The function of the cardiomyocyte sphingosine-1-phosphate receptor 1 (S1P1) in vivo is unknown. METHODS AND RESULTS Cardiomyocyte-restricted deletion of S1P1 in mice (S1P1 (α) (MHCC) (re)) resulted in(More)
Patients treated for gynaecological cancer by combined external irradiation and intravaginal radium application participated in two randomized, controlled, and prospective trials. In the first trial the incidence of deep vein thrombosis (DVT) diagnosed by the 125I-fibrinogen test was 43% in the control group. The injection of 7,500 i.u. of subcutaneous(More)
We examined the effect of locally infused thrombin on rabbit neck veins, using autologous [111In]indium-labeled platelets on the vessel wall. However, when the animals were pre-treated with aspirin (10 mg/kg), there was a marked change in the ratio of radioactive counts between control and treated segments, consistent with platelet deposition on the walls(More)
In order to investigate the influence of a cell-cycle specific agent on the cytokinetic behavior of a leukemic cell population in vivo, labeling studies with tritiated thymidine (3HTDR) followed by administration of vincristine (VCR) were performed on thymic cells of advanced AKR leukemic mice and evaluated utilizing a combined(More)
Effect of perinatal dex Rats received a single subcutaneous injection of 1 mg/kg dexamethasone at the age of seven days. One hundred days after the treatment, conditioned taste aversion was determined in the adult animals. Perinatally applied dexamethasone did not affect water consumption but caused a significant attenuation of conditioned taste aversion.(More)
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