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Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

• Robert W. Mahley, Karl H. Weisgraber, Ya-dong Huang
• Proceedings of the National Academy of Sciences…
• 2006

The premise of this review is that apolipoprotein (apo) E4 is much more than a contributing factor to neurodegeneration. ApoE has critical functions in redistributing lipids among CNS cells for… (More)

Plasma lipoproteins: apolipoprotein structure and function.

• Robert W. Mahley, Thomas L. Innerarity, Stanley C. Rall, Karl H. Weisgraber
• Journal of lipid research
• 1984

Plasma lipoprotein metabolism is regulated and controlled by the specific apolipoprotein (apo-) constituents of the various lipoprotein classes. The major apolipoproteins include apoE, apoB, apoA-I,… (More)

Apolipoprotein E: structure-function relationships.

• Karl H. Weisgraber
• Advances in protein chemistry
• 1994

Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS.

• Robert W. Mahley, Karl H. Weisgraber, Ya-dong Huang
• Journal of lipid research
• 2009

Apolipoprotein (apo) E has roles beyond lipoprotein metabolism. The detrimental effects of apoE4 in cardiovascular, neurological, and infectious diseases correlate with its structural features (e.g.,… (More)

Apolipoprotein E structure: insights into function.

• Danny M Hatters, Clare A Peters-Libeu, Karl H. Weisgraber
• Trends in biochemical sciences
• 2006

Human apolipoprotein E (apoE) is a member of the family of soluble apolipoproteins. Through its interaction with members of the low-density lipoprotein receptor family, apoE has a key role in lipid… (More)

Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro.

• Britto P Nathan, Stefano Bellosta, David A. Sanan, Karl H. Weisgraber, Robert W. Mahley, Robert E. Pitas
• Science
• 1994

Apolipoprotein E4 (apoE4), one of the three common isoforms of apoE, has been implicated in Alzheimer's disease. The effects of apoE on neuronal growth were determined in cultures of dorsal root… (More)

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

• Robert E. Pitas, J K Boyles, Seung Hun Lee, Dongwei Hui, Karl H. Weisgraber
• The Journal of biological chemistry
• 1987

This study was undertaken to determine if apolipoprotein (apo) E-containing lipoproteins and their receptors could provide a system for lipid transport and cholesterol homeostasis in the brain, as… (More)

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

• Warren J. Strittmatter, Karl H. Weisgraber, +7 authors A. D. Roses
• Proceedings of the National Academy of Sciences…
• 1993

Apolipoprotein E (apoE), a plasma apolipoprotein that plays a central role in lipoprotein metabolism, is localized in the senile plaques, congophilic angiopathy, and neurofibrillary tangles of… (More)

Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.

• Charles Bo Wilson, Mark R. Wardell, Karl H. Weisgraber, Robert W. Mahley, David A. Agard
• Science
• 1991

Human apolipoprotein E, a blood plasma protein, mediates the transport and uptake of cholesterol and lipid by way of its high affinity interaction with different cellular receptors, including the… (More)

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.

• Faith M Harris, Walter J. Brecht, +11 authors Ya-dong Huang
• Proceedings of the National Academy of Sciences…
• 2003

Apolipoprotein (apo) E4 increases the risk and accelerates the onset of Alzheimer's disease (AD). However, the underlying mechanisms remain to be determined. We previously found that apoE undergoes… (More)

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