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- Karl Friehs
- Advances in biochemical engineering/biotechnology
- 2004
Many expression systems in research and industry use plasmids as vectors for the production of recombinant proteins or non-proteinous recombinant substances. Plasmids have an essential impact on… (More)
- Johanna-Gabriela Walter, Oznur Kökpinar, Karl Friehs, Frank Stahl, Thomas Scheper
- Analytical chemistry
- 2008
Aptamers are short single-stranded DNA or RNA oligonucleotides that can bind to a wide range of target molecules with high affinity and specificity. As nucleic acids, aptamers can undergo… (More)
- Gerhard Miksch, Richard L Neitzel, E Fiedler, Karl Friehs, Erwin Flaschel
- Applied Microbiology and Biotechnology
- 1997
Cultivation conditions for the extracellular production of a hybrid β-glucanase from Bacillus were established by using Escherichiacoli JM109 carrying the plasmid pLF3. This plasmid contained a novel… (More)
- Chandran Vijayendran, Tino Polen, Volker F Wendisch, Karl Friehs, Karsten Niehaus, Erwin Flaschel
- Journal of biotechnology
- 2007
The use of Escherichia coli as a model organism has provided a great deal of basic information in biomolecular sciences. Examining trait differences among closely related strains of the same species… (More)
- Carsten Voss, Torsten T. Schmidt, Martin Schleef, Karl Friehs, Erwin Flaschel
- Journal of biotechnology
- 2003
Production of nucleic acids as an active pharmaceutical ingredient (API) in gene therapy and genetic vaccination is gaining more and more importance. Non-viral vectors like plasmid DNA are currently… (More)
- P. K. Kumar, H E Maschke, Karl Friehs, Karl Schügerl
- Trends in biotechnology
- 1991
Exploitation of recombinant organisms for the large-scale, commercial production of foreign proteins is often hampered by the problem of plasmid instability. A wide range of strategies have been… (More)
- Ning Wei, Jia You, Karl Friehs, Erwin Flaschel, Tim W. Nattkemper
- Biotechnology and bioengineering
- 2007
Fermentation industries would benefit from on-line monitoring of important parameters describing cell growth such as cell density and viability during fermentation processes. For this purpose, an in… (More)
- Benjamin Sommer, Karl Friehs, Erwin Flaschel
- Journal of biotechnology
- 2010
Aiming to facilitate the accessibility of recombinant proteins produced with Escherichia coli, extracellular expression may be achieved by means of bacteriocin release protein (BRP) coexpression.… (More)
- Gerhard Miksch, S. Kleist, Karl Friehs, Erwin Flaschel
- Applied Microbiology and Biotechnology
- 2002
The gene for phytase from Escherichia coli was sequenced and compared with the appA gene. It was found to be a mutant derivative of the appA gene. After fusion with a C-terminal His-tag, phytase was… (More)
- Yinghua Lu, Jaco C. Knol, Maarten H. K. Linskens, Karl Friehs, Peter J M van Haastert, Erwin Flaschel
- Journal of biotechnology
- 2004
Human Fas ligand (hFasL) is of considerable interest since it is a type II transmembrane glycoprotein that induces programmed cell death, or apoptosis. In this study Dictyostelium discoideum was used… (More)