Karl E.V. Burgess

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BACKGROUND/AIMS There is still debate about the relationship between fat accumulation and mitochondrial function in nonalcoholic fatty liver disease. It is a critical question as only a small proportion of individuals with steatosis progress to steatohepatitis. In this study, we focused on defining (i) the effects of triglyceride accumulation and reactive(More)
Acute canine polyradiculoneuritis (ACP) is considered to be the canine equivalent of the human peripheral nerve disorder Guillain-Barré syndrome (GBS); an aetiological relationship, however, remains to be demonstrated. In GBS, anti-glycolipid antibodies (Abs) are considered as important disease mediators. To address the possibility of common Ab biomarkers,(More)
The ability to phenotype metabolic profiles in serum has increased substantially in recent years with the advent of metabolomics. Metabolomics is the study of the metabolome, defined as those molecules with an atomic mass less than 1.5 kDa. There are two main metabolomics methods: mass spectrometry (MS) and proton nuclear magnetic resonance ((1)H NMR)(More)
The relationship between glucose and lipid metabolism has been of significant interest in understanding the pathogenesis of obesity-induced insulin resistance. To gain insight into this metabolic paradigm, we explored the potential interplay between cellular glucose flux and lipid-induced metabolic dysfunction within skeletal muscle. Here, we show that(More)
1 Department of Diabetes and Endocrinology, University of Edinburgh and Royal Infirmary of Edinburgh, Edinburgh, UK 2 Department of Hepatology, University of Edinburgh and Royal Infirmary of Edinburgh, Edinburgh, UK 3 Department of Clinical Biochemistry, University of Edinburgh and Royal Infirmary of Edinburgh, Edinburgh, UK 4 The Scottish Metabolomics(More)
1 Division of Cell Signalling and Immunology, Sir James Black Centre, College of Life Sciences, University of Dundee, Dundee, DD1 5EH, UK. 2 Division of Endocrinology, Diabetology, Angiology, Nephrology, Pathobiochemistry and Clinical Chemistry, Department of Internal Medicine, University Tuebingen, Germany. 3 Institute for Diabetes Research and Metabolic(More)
The prasinophytes (early diverging Chlorophyta), consisting of simple unicellular green algae, occupy a critical position at the base of the green algal tree of life, with some of its representatives viewed as the cell form most similar to the first green alga, the ‘ancestral green flagellate’. Relatively large-celled unicellular eukaryotic phytoflagellates(More)
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