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Necropsy brain tissue from normal (control) patients and patients with depression and dementia was examined for activities of various cholinergic components, and these related to the degree of senile plaque formation and extent of intellectual impairment. Choline acetyltransferase and acetylcholinesterase activities decreased significantly as the mean(More)
Insulin glargine is processed in vivo into soluble 21(A) -Gly-human insulin (M1), the principal moiety responsible for metabolic effects, and subsequently into M2. This sub-study compared metabolism and metabolite pharmacokinetic (PK) profiles of investigational new insulin glargine U300 (Gla-300) with insulin glargine 100 U/ml (Gla-100, Lantus®,(More)
BACKGROUND The occurrence of allergic multimorbidity (coexistence of asthma, allergic rhinitis and eczema) has not been evaluated longitudinally from early childhood up to adulthood in a population-based study sample. We aimed to determine the prevalence of allergic multimorbidity up to age 20 stratified by parental allergies and sex/gender using extensive(More)
BACKGROUND A novel non-invasive asthma prediction tool from the Leicester Cohort, UK, forecasts asthma at age 8 years based on 10 predictors assessed in early childhood, including current respiratory symptoms, eczema, and parental history of asthma. OBJECTIVE We aimed to externally validate the proposed asthma prediction method in a German birth cohort.(More)
permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver Introduction: Bullous lesions are common skin lesions particularly in(More)
OBJECTIVES The purpose of this cadaveric study was to determine the proximity of the neurologic structures to the path of the screw inserted percutaneously into the ischial tuberosity. DESIGN Cadaver study. INTERVENTION Ten screws were inserted in 10 limbs (5 cadavers) under fluoroscopic guidance. Dissection was then performed to expose the head of the(More)
A review of the literature on sleeping "disorders" in infants and toddlers shows that sleep problems are very common. We report the results of a German multicenter epidemiological study on a birth cohort (N = 1314). The children had medical examinations at 4 weeks, 3 months, 6 months, 1 year, 18 months, 2 years and 3 years. Most of the information on the(More)
The recurrent laryngeal nerve was transsected unilaterally and a device for electrical stimulation of the denervated muscles was implanted in 6 dogs. After 3 to 11 months the laryngeal muscles were obtained and histopathologically demonstrated a striking neurogenic pattern. In place of homogeneous muscle fiber atrophy, a patchwork of grouped fibre atrophy,(More)
Electrical stimulation of the posterior cricoarytenoid muscle, synchronized with inspiration, was achieved in dogs, utilizing a radio frequency stimulus triggered by a chest wall expansion transducer. This system brings about the abduction of the paralyzed vocal cord for the entire duration of inspiration, which allows a normal flow of air through the(More)
Patients with bilateral paresis of the recurrent laryngeal nerves have primarily breathing difficulties. But on the other hand the common operations for widening the glottis produce voice problems. To overcome these difficulties a muscle stimulation device was developed, which is triggered by the inspiratory motion of the thorax. With this device impulses(More)