Karl Dietmann

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The LD50's of various solvents frequently used in toxicological work to improve the solubility of otherwise poorly soluble compounds were determined in the mouse and rat. The substances investigated were ethanol, dimethylacetamide, dimethylformamide, dimethylsulfoxide, glycerine, N-methylpyrrolidone, polyethylene glycol 400, 1,2-propanediol and Tween 20.(More)
Whereas the clinical efficacy of isosorbide-5-mononitrate (IS-5-MN) in angina pectoris has been demonstrated unequivocally, the action of the substance on acute myocardial ischemia in animal models has not been investigated yet. Therefore, IS-5-MN and, for comparison in some experiments, isosorbide dinitrate and isosorbide-2-mononitrate were studied on a(More)
The aim of this study was to determine pharmacokinetic data of isosorbide-5-mononitrate (IS-5-MN) in dogs and to correlate them with the hemodynamic effects of this drug. Beagle dogs (n = 7) were given 3 mg/kg of IS-5-MN, the main metabolite of isosorbide-dinitrate, by i.v. injection and oral administration. At defined times blood samples were withdrawn(More)
The new beta-blockers 4-(2-hydroxy-3-isopropyl-amino-propoxy)-carbazole (carazolol) and 1-(4-acetoxy-2,3,5-trimethylphenyloxy)-3-isopropylamino-propan-2-ol (methypranol, Disorat) were compared with 14 well-known beta-blocking agents with regard to isoproterenol antagonism (equipotent doses in the rabbit i.v.), acute toxicity (LD50 in mice i.v.) and(More)
In conscious dogs, blood flow in the circumflex branch of the left coronary artery was measured with electromagnetic flowmeters. Myocardial anoxia followed by reactive hyperemia was produced by occluding the artery with a pneumatic cuff for up to 120 sec. 1. The interval between the beginning and the maximum of reactive hyperemia increased with the duration(More)
The antiarrhythmic and acute toxic actions of quinidine (Q) and dihydroquinidine (DHQ) were investigated in experiments in rats. 1. No significant difference was found between Q and DHQ with regard to the doses necessary to suppress electrically induced ventricular fibrillation in the heart (p greater than 0.05). 2. On oral administration, pure DHQ was(More)
The coronary blood flow of 5 conscious dogs was recorded continuously with electromagnetic flowmeters. A temporary local hypoxia of the myocardium induced by means of a pneumatic blood vessel occuluder was followed by a reactive hyperemia. Theophylline prevented the increase in coronary blood flow during adenosine infusion but not the reactive hyperemia.(More)
The effect of 0.25 mg ouabain on cerebral blood flow (CBF) was investigated in patients with and without cerebrovascular disease using the xenon clearance method. The 36 patients included in this study did not show any signs of heart failure. Ouabain increased the CBF and this effect was demonstrable 15, as well as 90 min. after administration. This effect(More)