Single-chain antigen-binding proteins are novel recombinant polypeptides, composed of an antibody variable light-chain amino acid sequence (VL) tethered to a variable heavy-chain sequence (VH) by a designed peptide that links the carboxyl terminus of the VL sequence to the amino terminus of the VH sequence. These proteins have the same specificities and… (More)
Computer-generated pictures are essential for studying and comparing the structures of proteins that have been solved by x-ray crystallography. Stereoscopic pairs produced by a computer program are particularly useful in providing an intelligible portrayal of the molecular topology.
" blue-fluorescent antibody " EP2-19G2 should really be called a " blue-emissive " or " blue-luminescent " antibody. Because roughly 3 eV of photon energy is stored in the charge-transfer excited state, it is predicted to be both a powerful reductant and oxidant. We examined the redox activity of the charge-transfer state in experiments in which irradiation… (More)