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Using a microperfusion technique proximal tubular reabsorption of sulfamerazine, phenobarbital, p-aminohippuric acid, uric acid, sulfaurea and N4-acetylsulfamerazine was studied as a function of intratubular pH in the rat kidney in vivo. Transtubular permeabilities were related to in vitro lipoid solubility measurements and degrees of non-dissociation of(More)
The effect of co-administration of acyclovir andcis-diamminedichloroplatinum(II) (cisplatin) on nephrotoxicity in male Wistar rats was investigated. Animals received acyclovir (15 mg/kg body weight, s.c., three times per day for 5 days) or cisplatin (5 mg/kg body weight, i.p., one single injection) or a combination of both drugs. Acyclovir plasma levels(More)
Renal microsomes isolated on day 3 from cis-platin (CDDP, single i.p. injection, 4 or 6 mg/kg)-treated rats were monitored for their susceptibility to lipid peroxidation as compared with microsomes from rats treated with carboplatin (CBDCA, 30 mg/kg), transplatin (TDDP, 6 mg/kg) or CDDP hydrolysis products (4 or 6 mg/kg) or from control animals.(More)
First-, second-, and third-generation cephalosporins were investigated for their peroxidative and nephrotoxic potential. Renal cortical slices from male Wistar rats were incubated at 37° C for 1 h in a phosphate-buffered medium containing the cephalosporin (1.25, 2.5, 5 or 10 mg/ml). In another series of experiments 5 mg/ml cephalosporin was incubated under(More)
Pinocytosis was induced in rat kidney by exposure to horseradish peroxidase (HRP). Pinocytic vesicle preparations were enriched after homogenization of kidney cortex by differential centrifugation and free-flow electrophoresis with HRP as an exogenous marker. Vesicles were identified by enzymatic analysis and by electron microscopy, including specific(More)
Using a newly developed model of allergic contact dermatitis in pigs, calcineurin inhibitors of the tacrolimus and ascomycin type were shown to have a highly anti-inflammatory action after topical application. These findings provided the first pharmacological evidence of the efficacy of this novel class of topical agents in the treatment of inflammatory(More)
The immunosuppressive agent cyclosporin A (CyA) and the antiviral drug acyclovir may cause renal functional impairment. CyA-induced immunosuppression increases the rate of viral infections. Therefore we were interested to determine whether short-term co-administration of CyA and acyclovir involves an increased nephrotoxic risk. Male Wistar rats were treated(More)
The 17-alpha-substituted triterpene 1 [(17alpha)-23-(E)-dammara-20,23-diene-3beta,25-diol] showed promising activity in animal models of immunosuppression and inflammation. Using a mouse model for inflammatory skin diseases (oxazolone-induced allergic contact dermatitis, ACD) as the directing in vivo test system, Structure-activity-relationship studies with(More)
Sustaining participation in design is difficult, especially in neighborhoods that seek change consistent with their cultural values. Participatory Design offers several approaches (e.g. infrastructuring) that help to balance the sensibilities of urban planning with the immediacies of design. This paper investigates the distinctive value of a "constellation"(More)