Karl A. Franklin

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Hypoxaemia occurs with sleep apnoea and might induce nocturnal angina. Sleep apnoea was found in 9 of 10 patients with nocturnal angina pectoris. Nocturnal angina diminished during treatment of sleep apnoea by continuous positive airway-pressure, and the number of nocturnal myocardial ischaemic events measured by computerised vector-cardiography was reduced.
BACKGROUND The increase in asthma prevalence until 1990 has been well described. Thereafter, time trends are poorly known, due to the low number of high quality studies. The preferred method for studying time trends in prevalence is repeated surveys of similar populations. This study aimed to compare the prevalence of asthma symptoms and their major(More)
  • Marie Marklund, Karl A Franklin, Carin Sahlin, Rta, Rune Lundgren, Allergology Franklin +2 others
  • 1999
Objective: To evaluate the effects of a mandibular advancement device on apneas and sleep in mild, moderate, and severe obstructive sleep apnea. Design: Prospective study. Subjects: Forty-four of 47 patients included. Intervention: Individually adjusted mandibular advancement devices. Measurements: Polysomnographic sleep recordings for 1 night without the(More)
BACKGROUND Selection bias is a systematic error in epidemiologic studies that may seriously distort true measures of associations between exposure and disease. Observational studies are highly susceptible to selection bias, and researchers should therefore always examine to what extent selection bias may be present in their material and what characterizes(More)
The influence of position during sleep on central apnoeas during Cheyne-Stokes respiration has not previously been studied systematically. The current authors aimed to study the effect of body position and sleep stages on central sleep apnoeas during Cheyne-Stokes respiration. A total of 20 consecutive patients with cardiovascular diseases and central sleep(More)
BACKGROUND The prognostic role of the arterial blood gas tension of carbon dioxide (PaCO2) in severe Chronic Obstructive Pulmonary Disease (COPD) remains unknown. The aim of this study was to estimate the association between PaCO2 and mortality in oxygen-dependent COPD. METHODS National prospective study of patients starting long-term oxygen therapy(More)
BACKGROUND Women who smoke have higher risk of lung function impairment, COPD and lung cancer than smoking men. An influence of sex hormones has been demonstrated, but the mechanisms are unclear and the associations often subject to confounding. This was a study of wheeze in relation to smoking and sex with adjustment for important confounders. METHODS In(More)
  • Albert Bickford, Mike Cahill, Paul De Lacy, Karl Franklin, James Hafford, Clif Olson +5 others
  • 2005
Peter and the other apostles replied: " We must obey God rather than men! " (Acts 5.29) Optimality Theory (OT) is a formal linguistic model in which grammars consist of a universal set of violable constraints that are ranked in a language-particular hierarchy. Lower-ranked constraints are often forcibly violated in order to improve satisfaction of(More)
BACKGROUND There is little knowledge about how oral and respiratory health is interrelated even though the mucosa of the oral cavity and airways constitutes a continuum and the exposures to these are partly similar. AIMS To investigate whether gum bleeding is related to asthma, respiratory symptoms and self-reported COPD. METHODS A postal questionnaire(More)
IMPORTANCE Oral appliances that move the mandible forward during sleep are suggested as treatment for mild to moderate obstructive sleep apnea. OBJECTIVE To test whether an adjustable, custom-made oral appliance improves daytime sleepiness and quality of life in patients with daytime sleepiness and snoring or mild to moderate obstructive sleep apnea. (More)