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gfsA encodes a novel galactofuranosyltransferase involved in biosynthesis of galactofuranose antigen of O‐glycan in Aspergillus nidulans and Aspergillus fumigatus
TLDR
This is the first characterization of a fungal β‐galactofuranosyltransferase, which was shown to be involved in Galf antigen biosynthesis of O‐glycans in the Golgi.
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Chemical Mechanism of UDP-Galactopyranose Mutase from Trypanosoma cruzi: A Potential Drug Target against Chagas' Disease
TLDR
A detailed kinetic and chemical mechanism for the unique non-redox reaction of UGM is presented, showing for the first time that NADPH is an effective redox partner of TcUGM and supporting the proposal of the flavin acting as a nucleophile.
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Targeting UDP-Galactopyranose Mutases from Eukaryotic Human Pathogens
TLDR
It has become clear that UGMs from prokaryotic and eukaryotic organisms have different structural and mechanistic features, resulting in differences in oligomeric states, substrate binding, active site flexibility, and interaction with redox partners.
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Cationic glycopolymers for the delivery of pDNA to human dermal fibroblasts and rat mesenchymal stem cells.
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Substrate‐dependent dynamics of UDP‐galactopyranose mutase: Implications for drug design
TLDR
Computer simulations of T. cruzi UGM in the presence or absence of an active site ligand suggest a modular mechanism in which each moiety of the substrate controls the flexibility of a different protein loop and indicate that interactions with the substrate diphosphate moiety are especially important for stabilizing the closed active site.
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Correlation of amine number and pDNA binding mechanism for trehalose-based polycations.
TLDR
It was concluded that, depending on the number of secondary amines in the repeat unit, these polymers interact with pDNA via different mechanisms with varying extents of electrostatic interaction and hydrogen bonding, which may affect the ability of trehalose to serve as a deterrent against aggregation in serum conditions and lend insight into the roles of polymer-pDNA binding during the complex transfection process.
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Inhibition of the Flavin-Dependent Monooxygenase Siderophore A (SidA) Blocks Siderophore Biosynthesis and Aspergillus fumigatus Growth.
TLDR
Celastrol, a natural quinone methide, was identified as a noncompetitive inhibitor of SidA with a MIC value of 2 μM and docking experiments suggest that celastrol binds across the NADPH and l-Orn pocket.
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Flavin‐N5 Covalent Intermediate in a Nonredox Dehalogenation Reaction Catalyzed by an Atypical Flavoenzyme
TLDR
2‐HAH is established as a novel noncanonical flavoenzyme that catalyzes the conversion of 2‐chloroacrylate, a major component in the manufacture of acrylic polymers, to pyruvate.
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A fluorescence polarization binding assay to identify inhibitors of flavin-dependent monooxygenases.
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UDP-galactopyranose mutases from Leishmania species that cause visceral and cutaneous leishmaniasis.
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