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- Publications
- Influence
gfsA encodes a novel galactofuranosyltransferase involved in biosynthesis of galactofuranose antigen of O‐glycan in Aspergillus nidulans and Aspergillus fumigatus
- Yuji Komachi, S. Hatakeyama, +8 authors Takuji Oka
- Biology, Medicine
- Molecular microbiology
- 1 December 2013
The cells walls of filamentous fungi in the genus Aspergillus have galactofuranose (Galf)‐containing polysaccharides and glycoconjugates, including O‐glycans, N‐glycans, fungal‐type galactomannan and… Expand
Chemical Mechanism of UDP-Galactopyranose Mutase from Trypanosoma cruzi: A Potential Drug Target against Chagas' Disease
- Michelle Oppenheimer, A. L. Valenciano, Karina Kizjakina, Jun Qi, P. Sobrado
- Chemistry, Medicine
- PloS one
- 20 March 2012
UDP-galactopyranose mutase (UGM) is a flavoenzyme that catalyzes the conversion of UDP-galactopyranose to UDP-galactofuranose, the precursor of galactofuranose (Galf). Galf is found in several… Expand
Targeting UDP-Galactopyranose Mutases from Eukaryotic Human Pathogens
- Karina Kizjakina, J. Tanner, P. Sobrado
- Biology, Medicine
- Current pharmaceutical design
- 31 March 2013
UDP-Galactopyranose mutase (UGM) is a unique flavin-dependent enzyme that catalyzes the conversion of UDP-galactopyranose (UDP-Galp) to UDP-galactofuranose (UDP-Galf). The product of this reaction is… Expand
Cationic glycopolymers for the delivery of pDNA to human dermal fibroblasts and rat mesenchymal stem cells.
- Karina Kizjakina, Joshua M. Bryson, Giovanna Grandinetti, T. Reineke
- Materials Science, Medicine
- Biomaterials
- 1 February 2012
Progenitor and pluripotent cell types offer promise as regenerative therapies but transfecting these sensitive cells has proven difficult. Herein, a series of linear trehalose-oligoethyleneamine… Expand
Substrate‐dependent dynamics of UDP‐galactopyranose mutase: Implications for drug design
- Leonardo Boechi, Cesar Augusto F. Oliveira, +4 authors J. A. McCammon
- Biology, Medicine
- Protein science : a publication of the Protein…
- 1 November 2013
Trypanosoma cruzi is the causative agent of Chagas disease, a neglected tropical disease that represents one of the major health challenges of the Latin American countries. Successful efforts were… Expand
Correlation of amine number and pDNA binding mechanism for trehalose-based polycations.
- Lisa E. Prevette, M. Lynch, Karina Kizjakina, T. Reineke
- Chemistry, Medicine
- Langmuir : the ACS journal of surfaces and…
- 8 July 2008
Glycopolymers with repeat units comprised of the disaccharide trehalose and an oligoamine of increasing amine have been previously synthesized by our group and shown to efficiently deliver pDNA… Expand
UDP-galactopyranose mutases from Leishmania species that cause visceral and cutaneous leishmaniasis.
- Isabel O Fonseca, Karina Kizjakina, P. Sobrado
- Biology, Medicine
- Archives of biochemistry and biophysics
- 15 October 2013
Leishmaniasis is a vector-borne, neglected tropical disease caused by parasites from the genus Leishmania. Galactofuranose (Galf) is found on the cell surface of Leishmania parasites and is important… Expand
Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics
- I. D. da Fonseca, I. A. Qureshi, R. Mehra-Chaudhary, Karina Kizjakina, J. Tanner, P. Sobrado
- Biology, Medicine
- Biochemistry
- 20 November 2014
UDP-galactopyranose mutase (UGM) catalyzes the interconversion between UDP-galactopyranose and UDP-galactofuranose. Absent in humans, galactofuranose is found in bacterial and fungal cell walls and… Expand
A fluorescence polarization binding assay to identify inhibitors of flavin-dependent monooxygenases.
- Jun Qi, Karina Kizjakina, Reeder M Robinson, K. Tolani, P. Sobrado
- Biology, Medicine
- Analytical biochemistry
- 1 June 2012
N-Hydroxylating monooxygenases (NMOs) are essential for pathogenesis in fungi and bacteria. NMOs catalyze the hydroxylation of sine and ornithine in the biosynthesis of hydroxamate-containing… Expand
Inhibition of the Flavin-Dependent Monooxygenase Siderophore A (SidA) Blocks Siderophore Biosynthesis and Aspergillus fumigatus Growth.
- Julia S. Martín del Campo, N. Vogelaar, K. Tolani, Karina Kizjakina, K. Harich, P. Sobrado
- Biology, Medicine
- ACS chemical biology
- 15 September 2016
Aspergillus fumigatus is an opportunistic fungal pathogen and the most common causative agent of fatal invasive mycoses. The flavin-dependent monooxygenase siderophore A (SidA) catalyzes the oxygen… Expand