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Deep brain stimulation (DBS) is an established treatment for Parkinson’s disease. Success of DBS is highly dependent on electrode location and electrical parameter settings. The aim of this study was to develop a general method for setting up patient-specific 3D computer models of DBS, based on magnetic resonance images, and to demonstrate the use of such(More)
Spatial and temporal variations in forearm skin perfusion captured by laser Doppler perfusion imaging (LDI) have been compared with topographic maps recorded by laser Doppler flowmetry. In order to determine the shortest LDI sampling time required at each measurement site, with an adequate signal-to-noise ratio and with the ability to display the(More)
BACKGROUND/AIMS Laser Doppler perfusion imaging (LDPI) permits measurement of skin blood flow changes in patch test reactions. It is, as yet, unclear how collected data can best be handled and presented in order to maximize the possible discriminatory advantage of the imaging technique and to make the selection of data for statistical analysis as objective(More)
Laser Doppler perfusion imaging offers a new modality for in vivo monitoring of the superficial blood perfusion in biological tissue. In this study, the superficial blood perfusion of malignant non-melanoma skin tumours and the surrounding normal skin was measured in conjunction with photodynamic therapy (PDT) using topical delta-aminolaevulinic acid(More)
BACKGROUND Deep brain stimulation (DBS) requires precise and safe navigation to the chosen target. Optical measurements allow monitoring of gray-white tissue boundaries (total light intensity [TLI]) and microvascular blood flow during stereotactic procedures. OBJECTIVE To establish the link between TLI/blood flow and anatomy along trajectories toward the(More)
Quantification of blood fraction (f(blood)), blood oxygenation (S(O2)), melanin, lipofuscin and oxidised and reduced Cytochrome aa 3 and c was done from diffuse reflectance spectra captured in cortex, white matter, globus pallidus internus (GPi) and subthalamus during stereotactic implantations of 29 deep brain stimulation (DBS) electrodes with the aim of(More)
Models and simulations are commonly used to study deep brain stimulation (DBS). Simulated stimulation fields are often defined and visualized by electric field isolevels or volumes of tissue activated (VTA). The aim of the present study was to evaluate the relationship between stimulation field strength as defined by the electric potential V, the electric(More)
A novel bioanalytical in vivo sampling technique, cutaneous microdialysis, was used to follow the chronology of skin histamine release in 3 patients with cold urticaria and in 2 healthy volunteers. Laser Doppler perfusion imaging was used simultaneously to monitor the skin circulatory response. Microdialysis samples were collected at 10-min intervals and(More)
Imaging of tissue perfusion is important in assessing the influence of peripheral vascular disease on microcirculation. This paper reports on a laser Doppler perfusion imaging technique based on dynamic light scattering in tissue. When a laser beam sequentially scans the tissue (maximal area approximately 12 cm *12 cm), moving blood cells generate Doppler(More)