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Alzheimer's disease (AD) is a late-onset, progressive degenerative disorder that affects mainly the judgment, emotional stability, and memory domains. AD is the outcome of a complex interaction among several factors which are not fully understood yet; nevertheless, it is clear that oxidative stress and inflammatory pathways are among these factors. 65(More)
PURPOSE To evaluate, in a pilot study, the phosphorylated H2AX (γH2AX) foci approach for identifying patients with double-strand break (DSB) repair deficiencies, who may overreact to DNA-damaging cancer therapy. METHODS AND MATERIALS The DSB repair capacity of children with solid cancers was analyzed compared with that of age-matched control children and(More)
Universities and professional bodies require graduates to be skilled practitioners educated to a high standard of competency with proficiency in a diversity of graduate attributes. Some attributes are discipline based while others are of a more generic nature. Proficiency in the generic attribute of Information Literacy can provide the necessary scaffolding(More)
Aim: The aim of this study was to evaluate a new technique for the manual extraction of different drugs from postmortem brain samples. Methods: Homogenized brain tissue from a pig was spiked with a mixture of analytes. For sample pre-treatment, protein precipitation with acetonitrile was compared to direct dilution with phosphate buffer. Disposal pipette(More)
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