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  • Alexandra Makarova, Irina Mikhailenko, Thomas H Bugge, Karin List, Daniel A Lawrence, Dudley K Strickland
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2003 (First Publication: 12 December 2003)
  • Proteases contribute to a variety of processes in the brain; consequently, their activity is carefully regulated by protease inhibitors, such as neuroserpin. This inhibitor is thought to be secretedContinue Reading
  • Karin List, Christian C. Haudenschild, +6 authors Thomas H Bugge
  • Medicine, Biology
  • Oncogene
  • 2002 (First Publication: 1 May 2002)
  • Matriptase/MT-SP1 is a novel tumor-associated type II transmembrane serine protease that is highly expressed in the epidermis, thymic stroma, and other epithelia. A null mutation was introduced intoContinue Reading
  • Marguerite S. Buzza, Sarah Netzel-Arnett, +7 authors Toni M Antalis
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 2010 (First Publication: 8 February 2010)
  • The intestinal epithelium serves as a major protective barrier between the mammalian host and the external environment. Here we show that the transmembrane serine protease matriptase plays a pivotolContinue Reading
  • Kelly L. Mueller, Julie M. Madden, Gina L. Zoratti, Charlotte Kuperwasser, Karin List, Julie L. Boerner
  • Medicine
  • Breast Cancer Research
  • 2012 (First Publication: 12 July 2012)
  • IntroductionEpidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have shown clinical efficacy in lung, colon, and pancreatic cancers. In lung cancer, resistance to EGFR TKIsContinue Reading
  • Karin List, John P. Hobson, Alfredo A Molinolo, Thomas H Bugge
  • Biology, Medicine
  • Journal of cellular physiology
  • 2007 (First Publication: 1 October 2007)
  • Prostasin (CAP1/PRSS8) is a glycosylphosphatidylinositol-anchored membrane serine protease believed to be critical for the regulation of epithelial sodium channel (ENaC) activity. Prostasin isContinue Reading