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Consider the recovery of an unknown signal x from quantized linear measurements. In the one-bit compressive sensing setting, one typically assumes that x is sparse, and that the measurements are of the form sign((a<sub>i</sub>, x)) &#x03F5; {&#x00B1;1}. Since such measurements give no information on the norm of x, recovery methods typically assume that(More)
CD8 T cell memory critically contributes to long-term immunity. Both low- and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal strength is altered. To gain further insight into this question, we used a TCRβ transmembrane(More)
T cell responses to low-affinity T cell receptor (TCR) ligands occur in the context of infection, tumors, and autoimmunity despite diminished TCR signal strength. The processes that enable such responses remain unclear. We show that distinct mechanisms drive effector/memory development in high- and low-affinity T cells. Low-affinity cells preferentially(More)
Signals from the T-cell recognition of antigen program effector functions are necessary to clear infections and tumors. The JNK pathway is critically important in regulating this process. In T lymphocytes, JNK1 and JNK2 have distinct functions depending on their maturation state and cell-type. However, the mechanisms that regulate their isoform-specific(More)
CD8 T cells must integrate antigenic and inflammatory signals to differentiate into efficient effector and memory T cells able to protect us from infections. The mechanisms by which TCR signaling and proinflammatory cytokine receptor signaling cooperate in these processes are poorly defined. In this study, we show that IL-12 and other proinflammatory(More)
T-cell memory is critical for long-term immunity. However, the factors involved in maintaining the persistence, function, and phenotype of the memory pool are undefined. Eomesodermin (Eomes) is required for the establishment of the memory pool. Here, we show that in T cells transitioning to memory, the expression of high levels of Eomes is not constitutive(More)
A review of the latest results from the WA97 experiment on the strange particle production in Pb–Pb and p–Pb collisions is presented. Transverse mass spectra and yields of K 0 S , Λ, Ξ, Ω and h − (negatively charged particles) have been measured at central rapidity. Yields are studied as a function of the number of nucleons participating in the collision(More)
CD8 T cell memory critically contributes to long-term immunity. Both low-and high-affinity TCR signals are able to support the differentiation of memory CD8 T cells. However, it is unclear whether the requirements for memory development change when TCR signal strength is altered. To gain further insight into this question, we used a TCRb transmembrane(More)