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BACKGROUND Mad1 and Mad2 are constituents of the spindle-assembly checkpoint, a device coupling the loss of sister-chromatid cohesion at anaphase to the completion of microtubule attachment of the sister chromatids at metaphase. Fluorescence recovery after photobleaching (FRAP) revealed that the interaction of cytosolic Mad2 with kinetochores is highly(More)
H3K27me3 is deposited at promoters by the preferential association of Polycomb repressive complex 2 (PRC2) with CpG-rich DNA elements regulating development by repressing gene transcription. H3K27 is also present in mono- and dimethylated states; however, the functional roles of H3K27me1 and H3K27me2 deposition remain poorly characterized. Here, we show(More)
  • Van Der Borght, K Ferrari, +16 authors Edwin H
  • 2007
Hippocampal cell proliferation across the day: increase by running wheel activity, but no effect of sleep and wakefulness. Differential involvement of hippocampal calcineurin during learning and reversal learning in a Y-maze task. Learning & Memory 13(6):753-9. Exercise improves memory acquisition and retrieval in the Y-maze task: relationship with(More)
Leukemia is a complex heterogeneous disease often driven by the expression of oncogenic fusion proteins with different molecular and biochemical properties. Whereas several fusion proteins induce leukemogenesis by activating Hox gene expression (Hox-activating fusions), others impinge on different pathways that do not involve the activation of Hox genes(More)
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