Karin Hofstetter

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The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol] and its close analog CGP13501 were identified as positive modulators of gamma-aminobutyric acid(B) (GABA(B)) receptor function. They potentiate GABA-stimulated guanosine 5'-O-(3-[(35)S]thiotriphosphate) (GTP gamma[(35)S]) binding to membranes from a GABA(B(1b/2)) expressing(More)
The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2dimethyl-propyl)-phenol] and its close analog CGP13501 were identified as positive modulators of -aminobutyric acidB (GABAB) receptor function. They potentiate GABA-stimulated guanosine 5 -O-(3-[S]thiotriphosphate) (GTP [S]) binding to membranes from a GABAB(1b/2) expressing Chinese hamster ovary(More)
Pseudomonas sp. VLB120 uses styrene as a sole source of carbon and energy. The first step in this metabolic pathway is catalyzed by an oxygenase (StyA) and a NADH-flavin oxidoreductase (StyB). Both components have been isolated from wild-type Pseudomonas strain VLB120 as well as from recombinant Escherichia coli. StyA from both sources is a dimer, with a(More)
This paper contains a report on a selection of recent research projects carried out at the Institute for Mechanics of Materials and Structures of Vienna University of Technology. The aim of this report is to demonstrate that Computational Mechanics of Materials and Structures is a scientific field with many characteristics of an electronic golem.
We report the first example of direct electrochemical regeneration of a flavin-dependent monooxygenase for asymmetric epoxidation catalysis. It is shown that electrochemical regeneration of the oxygenase subunit of the multicomponent styrene monooxygenase is sufficient to perform enantiospecific S-epoxidation of various styrene derivatives. Kinetic(More)
Electronic speckle pattern interferometry was applied to directly measure the distribution of longitudinal, tangential, and shear strains in small boards of Norway spruce (Picea abies (L.) Karst.) exposed to tensile load in longitudinal direction. A sample with a central intergrown knot and one with an equivalent loose knot were compared with reference(More)
The interrelationships between microstructural characteristics and anisotropic elastic properties of strand-based engineered wood products are highly relevant in order to produce custom-designed strand products with tailored properties. A model providing a link between these characteristics and the resulting elastic behavior of the strand products is a very(More)
Radionuclide myeloscintigraphy has previously been used to demonstrate subarachnoid fistulae. In the present case a patient with bronchogenic carcinoma developed spontaneous pneumocephalus postoperatively. Chest radiographs showed an air-fluid level in the postoperative area. Various diagnostic tests were used, but only a radionuclide myeloscintigram showed(More)
Biocatalytic oxygenation chemistry is a rapidly evolving field in which monooxygenases are the tools of choice. Monooxygenases catalyze many industrially important synthetic transformations; however, their use in preparative applications is hampered by their intrinsic requirement for reducing equivalents. As a result, non-enzymatic strategies--where the(More)