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The examination of learning and memory processes by a conditional reflectory locomotor avoidance reaction on 8-, 10-, 12-, 14-, 16-, 20-, 26-, and 50-week-old rats with spontaneous hypertension (SHR Okamoto/Aoki) revealed, up to an age of 20 weeks, correlations between the height of blood pressure and learning and memory performance by analogy with(More)
The relations between a perinatal exposure schedule and the outcome of dopamine (DA) release from striatum slices on the one hand and behaviour on the other, were studied in order to identify the vulnerable period. A mild chronic postnatal hypoxia (2nd-10th day of life) induces long-term effects on the DA release rate (FER) from striatum slices. A 10 h(More)
In male rats treated with pargyline, reserpine or pyridostigmine during neonatal life significant permanent changes of sexual behaviour and conditioned learning behaviour were observed in juvenile and/or adult life. Male sexual activity and learning capacity were permanently decreased in neonatally pargyline- or reserpine-treated animals, but permanently(More)
The injection of 250 microgram/kg SP-analogue (Lys-Phe-Ile-Gly-Leu-MetNH2) is able to restore the reduced or disturbed delta activities and paradoxical sleep periods of the sleeping EEG in chronically stressed rats. Thus it has been proved that Substance P, which we would like to term as an ,,regulatory peptide" (equal to regulide) has a modulating(More)
OBJECTIVES Hemopoietic cytokines regulate hemopoietic cell functions via specific cell surface receptors. There is evidence to suggest, that those receptors (R) could play a role in leukemia with respect to cell differentiations and its regulation, prognosis, and pathobiology. Knowledge of individual cytokine receptor (CKR) profiles could provide new(More)
Costimulatory molecules such as lymphocyte function-associated antigen (LFA)-1 (CD11a), LFA-3 (CD58), intercellular adhesion molecule (ICAM)-1 (CD54), neuronal cell adhesion molecule (NCAM) (CD56), B7-1 (CD80), or B7-2 (CD86) are important regulatory elements in healthy immunological cascades, but their role in acute myeloid leukemia (AML) has only been(More)
We studied the influence of time and period of application of substance P (SP) on type and size of the effects on learning in Wistar rats. Treatment with SP before acquisition training had a fascillitating effect on learning. If SP was applied from the 1st or 3rd d of acquisition training there was no effect; if given from the 2nd d an inhibition was found;(More)
Rats deprived temporarily of maternal contact and nutrition from the 3rd to 14th day of life showed decreased emotionality and poor memory capacity when tested in adulthood. Simultaneous administration of choline chloride, an acetylcholine precursor, in neonatal life permanently increased the emotionality and restored memory capacity to levels of control(More)