Karin A. Lecuona

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OBJECTIVE To assess the value of routine polymerase chain reaction (PCR) analysis on intraocular fluid from patients presenting with a first episode of suspected active infectious posterior uveitis in a population with a high prevalence of human immunodeficiency virus infection. DESIGN Retrospective, interventional case series. Participants. 159(More)
OBJECTIVE To report on conservation of eyes with choroidal melanoma with a multimodality approach to treatment. DESIGN Prospective, noncomparative, interventional case series. PARTICIPANTS All 1632 patients with choroidal melanoma treated at a single center between 1993 and 2002. INTERVENTION Primary enucleation (35%), brachytherapy (31.3%), proton(More)
Cataract is the leading cause of blindness in South Africa, responsible for about 50% of the prevalence of blindness and identified as a national health priority. The cataract surgery rate (CSR) should be at least 2 000 per million population per year for elimination of cataract blindness. The national CSR target was planned to increase from 1 000 in 2005(More)
PURPOSE The aim of this study is to identify and grade the severity of chronic ocular complications in patients who suffered from Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) treated in Cape Town, South Africa. METHODS A total of 54 patients with SJS or TEN for 6 months or longer were examined. The ocular complications were(More)
Ocular tumours present a therapeutic challenge because of the sensitive tissues involved and the necessity to destroy the tumour while minimising visual loss. Radiotherapy (RT) is one of several modalites used apart from surgery, laser, cryotherapy, and chemotherapy. Both external beam RT (EBRT) and brachytherapy are used. Tumours of the bulbar conjunctiva,(More)
Brachytherapy is one method of irradiating the orbit after enucleation of an eye with a malignant tumor that has a potential to recur. It consists of 6 trains of I-125 seeds placed around the periphery of the orbit, a shorter central train, and a metal disc, loaded with seeds, placed beneath the eyelids. The presence of a prosthetic orbital implant requires(More)
PURPOSE Children with retinoblastoma that extends into or through the choroid, sclera, or optic nerve are at risk of developing orbital disease, as well as metastases. Previously, these enucleated orbits were treated with external beam radiotherapy in addition to chemotherapy. 125I brachytherapy for tumors in and around the eye was pioneered by Sealy in(More)
PURPOSE To estimate the prevalence and causes of blindness and visual impairment in Cape Town, South Africa and to explore socio-economic and demographic predictors of vision loss in this setting. METHODS A cross sectional population-based survey was conducted in Cape Town. Eighty-two clusters were selected using probability proportionate to size(More)
AIM To evaluate the diagnostic accuracy of methylene blue used as a non-invasive in vivo stain to detect ocular surface squamous neoplasia (OSSN). METHODS A test validation study was performed according to Standards for the reporting of diagnostic accuracy studies (STARD) guidelines on 75 consecutive patients who presented with ocular surface lesions(More)
Schneiderian papillomas are benign tumours, with an aggressive nature. A case with a recurrent Schneiderian papilloma of the nasolacrimal sac, who underwent an external dacryocystorhinostomy (DCR) with irrigation of the nasolacrimal system with 0.02% mitomycin C (MMC), is presented at 18 months follow-up. External DCR using MMC, as an adjuvant therapy, is a(More)