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- Publications
- Influence
Hypoxia inducible factor activates the transforming growth factor-alpha/epidermal growth factor receptor growth stimulatory pathway in VHL(-/-) renal cell carcinoma cells.
- Lakshman Gunaratnam, M. Morley, +6 authors S. Lee
- Medicine
- The Journal of biological chemistry
- 2003
Bi-allelic-inactivating mutations of the VHL tumor suppressor gene are found in the majority of clear cell renal cell carcinomas (VHL(-/-) RCC). VHL(-/-) RCC cells overproduce hypoxia-inducible genes… Expand
HIF activation by pH-dependent nucleolar sequestration of VHL
- Karim Mekhail, L. Gunaratnam, Marie-Ève Bonicalzi, S. Lee
- Biology, Medicine
- Nature Cell Biology
- 1 July 2004
Hypoxia and acidosis occur in a wide variety of physiological and pathological settings that include muscle stress, tumour development and ischaemic disorders. A central element in the adaptive… Expand
Perinuclear cohibin complexes maintain replicative life span via roles at distinct silent chromatin domains.
- J. Y. Chan, Betty P K Poon, Jayesh S. Salvi, Jonathan B. Olsen, A. Emili, Karim Mekhail
- Biology, Medicine
- Developmental cell
- 14 June 2011
Heterochromatin, or silent chromatin, preferentially resides at the nuclear envelope. Telomeres and rDNA repeats are the two major perinuclear silent chromatin domains of Saccharomyces cerevisiae.… Expand
Regulation of ubiquitin ligase dynamics by the nucleolus
- Karim Mekhail, M. Khacho, A. Carrigan, Robert R.J. Hache, Lakshman Gunaratnam, S. Lee
- Biology, Medicine
- The Journal of cell biology
- 29 August 2005
Cellular pathways relay information through dynamic protein interactions. We have assessed the kinetic properties of the murine double minute protein (MDM2) and von Hippel-Lindau (VHL) ubiquitin… Expand
eEF1A is a novel component of the mammalian nuclear protein export machinery.
- M. Khacho, Karim Mekhail, Karine Pilon-Larose, A. Pause, J. Côté, Stephen Lee
- Biology, Medicine
- Molecular biology of the cell
- 1 December 2008
The cytoplasmic translation factor eEF1A has been implicated in the nuclear export of tRNA species in lower eukaryotes. Here we demonstrate that eEF1A plays a central role in nuclear export of… Expand
Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.
- K. Smith, L. Gunaratnam, M. Morley, A. Franovic, Karim Mekhail, S. Lee
- Biology, Medicine
- Cancer research
- 15 June 2005
Inactivating mutations in the von Hippel-Lindau (VHL) tumor suppressor gene are associated with clear cell renal cell carcinoma (VHL-/- RCC), the most frequent malignancy of the human kidney. The VHL… Expand
Regulation of Spo12 Phosphorylation and Its Essential Role in the FEAR Network
- Brett N. Tomson, R. Rahal, +4 authors A. Amon
- Biology, Medicine
- Current Biology
- 1 March 2009
BACKGROUND
In budding yeast, the protein phosphatase Cdc14 coordinates late mitotic events and triggers exit from mitosis. During early anaphase, Cdc14 is activated by the FEAR network, but how… Expand
Perinuclear tethers license telomeric DSBs for a broad kinesin- and NPC-dependent DNA repair process.
- Daniel K C Chung, J. Y. Chan, +6 authors Karim Mekhail
- Biology, Medicine
- Nature communications
- 24 July 2015
DNA double-strand breaks (DSBs) are often targeted to nuclear pore complexes (NPCs) for repair. How targeting is achieved and the DNA repair pathways involved in this process remain unclear. Here, we… Expand
Roles for Pbp1 and caloric restriction in genome and lifespan maintenance via suppression of RNA-DNA hybrids.
- Jayesh S. Salvi, J. Y. Chan, +7 authors Karim Mekhail
- Biology, Medicine
- Developmental cell
- 28 July 2014
Intergenic transcription within repetitive loci such as the ribosomal DNA (rDNA) repeats of yeast commonly triggers aberrant recombination. Major mechanisms suppressing aberrant rDNA recombination… Expand
Identification of a common subnuclear localization signal.
- Karim Mekhail, L. Rivero-Lopez, Ahmad Al-Masri, Caroline Brandon, M. Khacho, S. Lee
- Biology, Medicine
- Molecular biology of the cell
- 1 October 2007
Proteins share peptidic sequences, such as a nuclear localization signal (NLS), which guide them to particular membrane-bound compartments. Similarities have also been observed within different… Expand