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- Karim Mekhail, Lakshman Gunaratnam, Marie-Ève Bonicalzi, Stephen Q. S. Lee
- Nature Cell Biology
- 2004
Hypoxia and acidosis occur in a wide variety of physiological and pathological settings that include muscle stress, tumour development and ischaemic disorders. A central element in the adaptive… (More)
- Janet N. Y. Chan, Betty P. K. Poon, Jayesh S. Salvi, Jonathan B. Olsen, Andrew Emili, Karim Mekhail
- Developmental cell
- 2011
Heterochromatin, or silent chromatin, preferentially resides at the nuclear envelope. Telomeres and rDNA repeats are the two major perinuclear silent chromatin domains of Saccharomyces cerevisiae.… (More)
- Mireille Khacho, Karim Mekhail, Karine Pilon-Larose, Arnim Pause, Jocelyn Côté, Stephen Lee
- Molecular biology of the cell
- 2008
The cytoplasmic translation factor eEF1A has been implicated in the nuclear export of tRNA species in lower eukaryotes. Here we demonstrate that eEF1A plays a central role in nuclear export of… (More)
- Karlene Smith, Lakshman Gunaratnam, Melissa Morley, Aleksandra Franovic, Karim Mekhail, Stephen Q. S. Lee
- Cancer research
- 2005
Inactivating mutations in the von Hippel-Lindau (VHL) tumor suppressor gene are associated with clear cell renal cell carcinoma (VHL-/- RCC), the most frequent malignancy of the human kidney. The VHL… (More)
- Jayesh S. Salvi, Janet N. Y. Chan, +7 authors Karim Mekhail
- Developmental cell
- 2014
Intergenic transcription within repetitive loci such as the ribosomal DNA (rDNA) repeats of yeast commonly triggers aberrant recombination. Major mechanisms suppressing aberrant rDNA recombination… (More)
- Karim Mekhail, Mireille Khacho, Amanda Carrigan, Robert R.J. Hache, Lakshman Gunaratnam, Stephen Q. S. Lee
- The Journal of cell biology
- 2005
Cellular pathways relay information through dynamic protein interactions. We have assessed the kinetic properties of the murine double minute protein (MDM2) and von Hippel-Lindau (VHL) ubiquitin… (More)
- Lakshman Gunaratnam, Melissa Morley, +6 authors Stephen Q. S. Lee
- The Journal of biological chemistry
- 2003
Bi-allelic-inactivating mutations of the VHL tumor suppressor gene are found in the majority of clear cell renal cell carcinomas (VHL(-/-) RCC). VHL(-/-) RCC cells overproduce hypoxia-inducible genes… (More)
- Brett N. Tomson, Rami Rahal, +4 authors Angelika Amon
- Current Biology
- 2009
BACKGROUND
In budding yeast, the protein phosphatase Cdc14 coordinates late mitotic events and triggers exit from mitosis. During early anaphase, Cdc14 is activated by the FEAR network, but how… (More)
- Karim Mekhail, Mireille Khacho, Lakshman Gunaratnam, Stephen Q. S. Lee
- Cell cycle
- 2004
Hypoxia and acidosis are common features of several physiological and pathological situations, including cancer and stroke. The HIF (hypoxia-inducible factor) transcription factor plays a seminal… (More)
- Betty P. K. Poon, Karim Mekhail
- Cell cycle
- 2011
Interactions between genetic regions located across the genome maintain its three-dimensional organization and function. Recent studies point to key roles for a set of coiled-coil domain-containing… (More)