Karim Kassam

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The much publicized "Rule of 5" has been widely adopted among the pharmaceutical industry. It is used as a first step filter to perform virtual screening of compound libraries, in an effort to quickly eliminate lead candidates that have poor physicochemical properties for oral bioavailabilty. One of the key parameters used therein is log P, which is a(More)
This review summarizes progress made in the development of fully computational approaches to the prediction of blood-brain barrier (BBB) permeability of small molecules, with a focus on rapid computational methods suitable for the analysis of large compound sets and virtual screening. A comparative analysis using the recently developed Advanced Chemistry(More)
Ludwig's angina was first detailed by the German surgeon Wilhelm Friedrich von Ludwig in 1836. We present a case which needed awake fibreoptic intubation due to severe trismus and a prolonged period intubated in the Intensive Care Unit after incision and drainage of neck spaces and removal of his lower wisdom teeth. He was finally discharged a week after(More)
The face provides an important channel for communicating affect valence, the positive or negative emotional charge of an experience. This paper addresses the challenging pattern recognition problem of assigning affect valence labels (positive, negative or neutral) to facial action sequences obtained from unsegmented videos coded using the Facial Action(More)
Leishmaniasis is a disease that is caused by protozoa of the genus Leishmania, which is prevalent in tropical and subtropical areas. Clinical forms of leishmaniasis are particularly diverse representing a complex of diseases. We present a case of lingual Leishmaniasis in an immunocompetent man. The lesions were caused by Leishmania donovani/infantum(More)
The common sites for metastasis of renal cell carcinoma are lung, kidney, adrenal glands, liver, and contralateral kidney. We report an unusual case of cutaneous metastasis of renal cell carcinoma in a 68-year-old woman who was treated for renal cell carcinoma with partial right nephrectomy and multikinase angiogenesis inhibitor (sunitinib) 10 years ago.
4 Partisan identity shapes social, mental, economic, and physical life. Using a novel dataset, we 5 study the consequences of partisan identity by examining the immediate impact of electoral 6 loss and victory on happiness and sadness. Employing a quasi-experimental regression 7 discontinuity model we present two primary findings. First, elections strongly(More)
Ohnishi in 1975 first described temporomandibular joint (TMJ) arthroscopy. Along with its extensive use, a range of complications has emerged. We describe a patient who experienced parapharyngeal swelling after undergoing arthroscopy. Prolonged intubation up to 1 hour postoperatively was required. The swelling resolved completely over 6 h without further(More)
Partisan identity shapes social, mental, economic, and physical life. Using a novel dataset, we study the consequences of partisan identity by examining the immediate impact of electoral loss and victory on happiness and sadness. Employing a quasi-experimental regression discontinuity model we present two primary findings. First, elections strongly affect(More)