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Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disorders.

• Karim Bouazoune, Robert E. Kingston
• Proceedings of the National Academy of Sciences…
• 2012

Mutations in the CHD7 gene cause human developmental disorders including CHARGE syndrome. Genetic studies in model organisms have further established CHD7 as a central regulator of vertebrate… (More)

Analysis of individual remodeled nucleosomes reveals decreased histone–DNA contacts created by hSWI/SNF

• Karim Bouazoune, Tina Branscombe Miranda, Peter A. Jones, Robert E. Kingston
• Nucleic acids research
• 2009

Chromatin remodeling enzymes use the energy of ATP hydrolysis to alter histone-DNA contacts and regulate DNA-based processes in eukaryotes. Whether different subfamilies of remodeling complexes… (More)

Methylation-sensitive single-molecule analysis of chromatin structure.

• Tina Branscombe Miranda, Theresa K. Kelly, Karim Bouazoune, Peter A. Jones
• Current protocols in molecular biology
• 2010

Methylation-sensitive single-molecule analysis of chromatin structure is a high-resolution method for studying nucleosome positioning. As described in this unit, this method allows for the analysis… (More)

ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light.

• Benedikt Heinrich, Karim Bouazoune, Matthias Wojcik, Udo Bakowsky, Olalla Vázquez
• 2019

We report a high-affinity photoswitchable DNA binder, which displays different nucleosome-binding capacities upon visible-light irradiation. Both photochemical and DNA-recognition properties were… (More)

Assembly, remodelled

• Karim Bouazoune, Robert E. Kingston
• eLife
• 2013

Biochemical assays reveal that nucleosome maturation and chromatin remodelling by the motor protein Chd1 are distinct, separable enzymatic activities.

Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disorders

• Karim Bouazoune, Robert E. Kingston
• Epigenetics & Chromatin
• 2013

Background Mutations in the CHD7 gene cause CHARGE, a developmental syndrome which affect most organs. In addition, CHD7 mutations also cause puberty and reproductive organ formation disorders such… (More)

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