Author pages are created from data sourced from our academic publisher partnerships and public sources.
- Publications
- Influence
Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disorders
- Karim Bouazoune, R. Kingston
- Biology
- Epigenetics & Chromatin
- 8 April 2013
Background Mutations in the CHD7 gene cause CHARGE, a developmental syndrome which affect most organs. In addition, CHD7 mutations also cause puberty and reproductive organ formation disorders such… Expand
Chromatin remodeling by the CHD7 protein is impaired by mutations that cause human developmental disorders
- Karim Bouazoune, R. Kingston
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 7 November 2012
Mutations in the CHD7 gene cause human developmental disorders including CHARGE syndrome. Genetic studies in model organisms have further established CHD7 as a central regulator of vertebrate… Expand
Analysis of individual remodeled nucleosomes reveals decreased histone–DNA contacts created by hSWI/SNF
- Karim Bouazoune, T. Miranda, P. Jones, R. Kingston
- Medicine, Biology
- Nucleic acids research
- 30 June 2009
Chromatin remodeling enzymes use the energy of ATP hydrolysis to alter histone–DNA contacts and regulate DNA-based processes in eukaryotes. Whether different subfamilies of remodeling complexes… Expand
Methylation‐Sensitive Single‐Molecule Analysis of Chromatin Structure
- T. B. Miranda, T. Kelly, Karim Bouazoune, P. Jones
- Biology, Medicine
- Current protocols in molecular biology
- 1 January 2010
Methylation‐sensitive single‐molecule analysis of chromatin structure is a high‐resolution method for studying nucleosome positioning. As described in this unit, this method allows for the analysis… Expand
The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase
- J. Brühl, Jonathan Trautwein, Agnes Schäfer, U. Linne, Karim Bouazoune
- Medicine, Biology
- Epigenetics & Chromatin
- 21 August 2019
BackgroundMaintenance of genome integrity during DNA replication is crucial to the perpetuation of all organisms. In eukaryotes, the bypass of DNA lesions by the replication machinery prevents… Expand
ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light.
- Benedikt Heinrich, Karim Bouazoune, M. Wojcik, U. Bakowsky, O. Vázquez
- Chemistry, Medicine
- Organic & biomolecular chemistry
- 13 February 2019
We report a high-affinity photoswitchable DNA binder, which displays different nucleosome-binding capacities upon visible-light irradiation. Both photochemical and DNA-recognition properties were… Expand
Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology
- Yulia Kargapolova, Rizwan Rehimi, +22 authors A. Papantonis
- Biology
- 27 January 2020
Members of the chromodomain-helicase-DNA binding (CHD) protein family are chromatin remodelers critically implicated in human pathologies, with CHD6 being one of its least studied members. Here, we… Expand
CHD7 regulates cardiovascular development through ATP-dependent and -independent activities
- Shun Yan, Rassarin Thienthanasit, +7 authors K. Jiao
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 30 October 2020
Significance Mutation of CHD7 causes multiple developmental disorders, including CHARGE syndrome, in which conotruncal anomalies are the most prevalent form of heart defects. Our study provides mouse… Expand
CHD7 interacts with the nucleosome acidic patch for its efficient activity via its N-terminal region
- Eunhye Lee, C. Kang, +4 authors J. Song
- Chemistry, Biology
- 19 November 2020
Chromodomain-Helicase DNA binding protein 7 (CHD7) is an ATP dependent chromatin remodeler involved in maintaining open chromatin structure. Mutations of CHD7 gene causes multiple developmental… Expand