Karen Zagursky

Learn More
Repetitive behaviors are a core symptom domain in autism that has been linked to alterations in the serotonin system. While the selective serotonin-receptive inhibitor fluvoxamine has been shown to be effective in adults with autism, as yet no published placebo controlled trials with these agents document safety and efficacy in children with autism. This(More)
Atypical antipsychotics have been shown to improve disruptive and repetitive behaviors in pervasive developmental disorders (PDDs), but they require assessment of potential side effects. This is the first placebo-controlled trial of olanzapine in the treatment of children and adolescents with PDD. Eleven patients with a diagnosis of either autism,(More)
OBJECTIVES We sought to identify factors believed to facilitate or hinder evidence-based practice (EBP) implementation in public mental health service systems as a step in developing theory to be tested in future studies. METHODS Focusing across levels of an entire large public sector mental health service system for youths, we engaged participants from 6(More)
Velocardiofacial syndrome (VCFS) is a relatively common multi-anomaly disorder associated with a deletion on chromosome 22. Patients with VCFS have cardiac anomalies, cleft palate, learning problems, and speech and developmental delays. Previous studies found that mood and psychotic illnesses were the most common psychiatric disorders in patients with VCFS.(More)
The authors carried out a factor analysis of the Yale-Brown Obsessive-Compulsive Scale checklist at the category level in order to reduce the number of variables in this domain and ultimately identify possible endophenotypes; 181 children with autism were enrolled. The authors estimated a tetrachoric correlation matrix among the dichotomous symptom(More)
  • 1