Karen Y. Fung

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Septins are a family of GTP-binding proteins that assemble into cytoskeletal filaments. Unlike other cytoskeletal components, septins form ordered arrays of defined stoichiometry that can polymerize into long filaments and bundle laterally. Septins associate directly with membranes and have been implicated in providing membrane stability and serving as(More)
This study aimed at developing models to predict nitrogen dioxide (NO(2)) and sulfur dioxide (SO(2)) concentrations in Sarnia, "Chemical Valley", Ontario, Canada, and model the intra-urban variation of ambient NO(2) and SO(2) in the city for a community health study. NO(2) and SO(2) samples were monitored with Ogawa passive samplers at 39 locations across(More)
This study is part of a larger research program to examine the relationship between ambient air quality and health in Windsor, Ontario, Canada. We assessed the association between air pollution and daily respiratory hospitalization for different age and sex groups from 1995 to 2000. The pollutants included were nitrogen dioxide, sulfur dioxide, carbon(More)
Recurrent events, such as repeated hospital admissions for the same health outcome, occur frequently in environmental health studies. In this study, we conducted an analysis of data on repeated respiratory hospitalizations among the elderly in Vancouver, Canada, for the period of June 1, 1995, to March 31, 1999, using a new method proposed by (Dewanji and(More)
BACKGROUND Southwestern Ontario (SWO) in Canada has been known as a 'hot spot' in terms of environmental exposure and potential effects. We chose to study 3 major cities in SWO in this paper. We compared age-standardized hospital admission ratios of Sarnia and Windsor to London, and to generate hypotheses about potential pollutant-induced health effects in(More)
Brain tumor (BRAT) is a Drosophila member of the TRIM-NHL protein family. This family is conserved among metazoans and its members function as post-transcriptional regulators. BRAT was thought to be recruited to mRNAs indirectly through interaction with the RNA-binding protein Pumilio (PUM). However, it has recently been demonstrated that BRAT directly(More)
BACKGROUND scarring is an important component of overall acne severity, but there are no global scales for its evaluation inclusive of the face and trunk. OBJECTIVE our objective was to develop a global scale for acne scar severity inclusive of the trunk and the face. METHODS a six-category global severity scale (SCAR-S) was developed for assessment of(More)
BACKGROUND There is a paucity of information on the knowledge and understanding of patients with acne about their condition. OBJECTIVE The objective of this study is to evaluate the knowledge, beliefs, and perceptions of acne patients regarding their understanding of acne pathogenesis, sources of information, treatment options, and expectations. METHODS(More)
BACKGROUND Previous smaller studies suggest that age, gender, and duration of acne may individually be associated with clinical acne severity and quality of life (QoL) impact. OBJECTIVE Our purpose was to concurrently evaluate the association of demographic factors with clinical acne severity and with QoL impact. METHODS Clinical acne severity was(More)
In this paper, we examine the role that ambient air pollution plays in exacerbating cardiovascular and respiratory disease hospitalization in London, Ontario from 1 November 1995 to 31 December 2000. The number of daily cardiac and respiratory admissions was linked to concentrations of air pollutants (sulphur dioxide, nitrogen dioxide, ozone, carbon(More)