Karen Venables

Learn More
BACKGROUND 5-year results of the UK Standardisation of Breast Radiotherapy (START) trials suggested that lower total doses of radiotherapy delivered in fewer, larger doses (fractions) are at least as safe and effective as the historical standard regimen (50 Gy in 25 fractions) for women after primary surgery for early breast cancer. In this prespecified(More)
BACKGROUND The international standard radiotherapy schedule for early breast cancer delivers 50 Gy in 25 fractions of 2.0 Gy over 5 weeks, but there is a long history of non-standard regimens delivering a lower total dose using fewer, larger fractions (hypofractionation). We aimed to test the benefits of radiotherapy schedules using fraction sizes larger(More)
BACKGROUND The international standard radiotherapy schedule for breast cancer treatment delivers a high total dose in 25 small daily doses (fractions). However, a lower total dose delivered in fewer, larger fractions (hypofractionation) is hypothesised to be at least as safe and effective as the standard treatment. We tested two dose levels of a 13-fraction(More)
BACKGROUND AND PURPOSE Randomised trials testing 15- or 16-fraction regimens of adjuvant radiotherapy in women with early breast cancer have reported favourable outcomes compared with standard fractionation. To evaluate hypofractionation further, two 5-fraction schedules delivering 1 fraction per week have been tested against a 25-fraction regimen. (More)
OBJECTIVE The increasing use of tomotherapy and volumetric-modulated arc therapy in UK centres will result in more centres choosing to use this technology in a clinical trial setting. The Radiotherapy Trials Quality Assurance (RTTQA) group has developed a new procedure to integrate into the UK intensity-modulated radiotherapy (IMRT) credentialing programme(More)
PURPOSE Early breast cancer radiotherapy aims for local disease control and reduced recurrence. Treatment is directed to breast or chest wall alone using tangential fields, or includes regional lymph nodes with a separate anterior field. The complex geometry of this region necessitates matching adjacent radiation fields in three-dimensions. Potential exists(More)
PURPOSE To examine the ability of computer planning systems to calculate the dose to the breast correctly in three dimensions. Both the absolute dose at the center of the breast and the accuracy of the isodose distributions were investigated. METHODS AND MATERIALS Measurements were performed in a water-filled breast phantom using an ionization chamber.(More)
BACKGROUND Rotational IMRT (VMAT and Tomotherapy) has now been implemented in many radiotherapy centres. An audit to verify treatment planning system modelling and treatment delivery has been undertaken to ensure accurate clinical implementation. MATERIAL AND METHODS 34 institutions with 43 treatment delivery systems took part in the audit. A virtual(More)
AIMS To examine the effect of UK breast radiotherapy trials on the adoption of new radiotherapy techniques over the last 15 years. MATERIALS AND METHODS The data were taken from questionnaires returned to the national radiotherapy quality assurance team for each of the major trials (START, Supremo, FAST, IMPORT) with additional information sought from(More)