Karen Van Proeyen

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Endoplasmic reticulum (ER) stress in pancreas, liver, and adipose tissue is a key event in the pathogenesis of obesity-related metabolic disease. Lipid-induced ER stress in liver and adipose tissue leads to inhibition of insulin signaling. Whether this mechanism exists in skeletal muscle is currently unknown. The present study aimed at assessing the ER(More)
Nutrition is an important co-factor in exercise-induced training adaptations in muscle. We compared the effect of 6 weeks endurance training (3 days/week, 1–2 h at 75% VO2peak) in either the fasted state (F; n = 10) or in the high carbohydrate state (CHO, n = 10), on Ca2+-dependent intramyocellular signalling in young male volunteers. Subjects in CHO(More)
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