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  • Ronald Marcus, Arif Khan, +4 authors Raymond Sanchez
  • Bipolar disorders
  • 2011
OBJECTIVES To evaluate the efficacy and safety of aripiprazole (ARI) adjunctive to lithium (Li) or valproate (Val) (ARI+Li / Val) compared with placebo (PLB) adjunctive to Li or Val (PLB+Li / Val) as maintenance therapy for patients with bipolar I disorder who had an inadequate response to Li or Val monotherapy. METHODS Patients with a current manic/mixed(More)
We have determined the primary sequence and modification status of a transfer RNA from mosquito mitochondria whose GCU anticodon indicates that it is a serine tRNA (tRNASerGCU), and have obtained information on higher order structure using partial digestion with nucleases S1 and T1 under non-denaturing conditions. Although its primary sequence homology to(More)
OBJECTIVE To evaluate the efficacy and safety of aripiprazole versus placebo in preventing relapse of irritability symptoms associated with autistic disorder in pediatric patients. METHOD This multicenter, double-blind, randomized, placebo-controlled, relapse-prevention trial enrolled patients (6-17 years) who met the current Diagnostic and Statistical(More)
OBJECTIVES To evaluate the efficacy and safety of aripiprazole (ARI) plus lamotrigine (LTG) compared with placebo (PBO) plus LTG, for long-term treatment in bipolar I disorder patients with a recent manic/mixed episode. METHODS After a 9-24 week stabilization phase receiving single-blind ARI (10-30 mg/day) plus open-label LTG (100 or 200 mg/day), patients(More)
The 3'-terminal sequence of the large ribosomal subunit ("17S") RNA of hamster mitochondria has been examined by means of oligonucleotide fingerprint analysis of 3' end-labeled samples. Patterns from partial acid or alkaline hydrolysates indicated marked heterogeneity and suggested an array of termini that included GGUUAOH, AnAOH and AnGOH (where n is about(More)
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