Karen T. Lum

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Effort estimation often requires generalizing from a small number of historical projects. Generalization from such limited experience is an inherently underconstrained problem. Hence, the learned effort models can exhibit large deviations that prevent standard statistical methods (e.g., t-tests) from distinguishing the performance of alternative(More)
The proinflammatory cytokines IL-17A and IL-17F have a high degree of sequence similarity and share many biological properties. Both have been implicated as factors contributing to the progression of inflammatory and autoimmune diseases. Moreover, reagents that neutralize IL-17A significantly ameliorate disease severity in several mouse models of human(More)
There exists a large and growing number of proposed estimation methods but little conclusive evidence ranking one method over another. Prior effort estimation studies suffered from “conclusion instability”, where the rankings offered to different methods were not stable across (a) different evaluation criteria; (b) different data sources; or (c) different(More)
Bispecific antibodies (bsAbs) present an attractive opportunity to combine the additive and potentially synergistic effects exhibited by combinations of monoclonal antibodies (mAbs). Current challenges for engineering bsAbs include retention of the binding affinity of the parent mAb or antibody fragment, the ability to bind both targets simultaneously, and(More)
Results of an experiment designed to assess the usefulness of boric acid for preserving urine before its bacteriological examination are reported. Boric acid at a concentration of 20 g/l was found to be usefully bacteriostatic, largely eliminating the false positive results obtained with unpreserved specimens when delay before culture was more than 90 min.(More)
Previous studies from our laboratory on the feminization of the male mouse reproductive tract after prenatal exposure to diethylstilbestrol (DES) showed that the mRNA for the major estrogen-inducible uterine secretory protein, lactoferrin (LF), was constitutively expressed in the seminal vesicle of male mice exposed prenatally to DES, but not in the seminal(More)
1 There exists an extensive academic literature on software cost estimation that explores techniques such as boot strapping, assorted analogy methods such as nearest neighbor, and even highly non-linear ‘models’ such as decision trees. However, industry “best practice” virtually ignores the academic literature and continues to rely upon standard(More)
While there exists extensive literature on software cost estimation techniques, industry practice continues to rely upon standard regression-based algorithms. These software effort models are typically calibrated or tuned to local conditions using local data. This paper cautions that current approaches to model calibration often produce sub-optimal models(More)