Karen Sommer

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A naturally occurring 32-base pair deletion of the HIV-1 co-receptor CCR5 has demonstrated protection against HIV infection of human CD4(+) T cells. Recent genetic engineering approaches using engineered nucleases to disrupt the gene and mimic this mutation show promise for HIV therapy. We developed a megaTAL nuclease targeting the third extracellular loop(More)
Wnts are secreted ligands that activate several receptor-mediated signal transduction cascades. Homeo-static Wnt signaling through b-catenin is required in adults, because either elevation or attenuation of b-catenin function has been linked to diverse diseases. To contribute to the identification of both protein and pharmacological regulators of this(More)
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