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Costal2, a Novel Kinesin-Related Protein in the Hedgehog Signaling Pathway
It is shown that costal2 encodes a kinesin-related protein that accumulates preferentially in cells capable of responding to HH, and that CI associates with COS2 in a large protein complex, suggesting that C OS2 directly controls the activity of CI. Expand
The Effects of Caffeine on Sleep in Drosophila Require PKA Activity, But Not the Adenosine Receptor
It is suggested that chronic administration of caffeine promotes wakefulness in Drosophila, at least in part, by inhibiting cAMP phosphodiesterase activity. Expand
Sonic hedgehog in the nervous system: functions, modifications and mechanisms
Subsequent trafficking and organelle sorting in the Shh signaling pathway have been observed and offer a new dimension to the understanding of downstream signal transduction events. Expand
Differential regulation of Hedgehog target gene transcription by Costal2 and Suppressor of Fused
The mechanism by which the secreted signaling molecule Hedgehog (Hh) elicits concentration-dependent transcriptional responses from cells is not well understood. In the Drosophila wing imaginal disc,Expand
Hedgehog signal transduction proteins: contacts of the Fused kinase and Ci transcription factor with the Kinesin-related protein Costal2
This work identified and mapped direct interactions between Cos2, Fu, and Ci using an in vitro affinity assay and the yeast two-hybrid system to provide new insights into the possible mechanism of the cytosolic steps of Hedgehog transduction. Expand
Drosophila melanogaster: an insect model for fundamental studies of sleep.
The methods currently used to identify and characterize the Drosophila sleep state are reviewed and the powerful techniques afforded by this organism are likely to unveil deep insights into the function(s) and regulatory mechanisms of sleep. Expand