Karen Rokkedal Lausch

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BACKGROUND Observational studies have suggested that BCG may have nonspecific beneficial effects on survival. Low-birth-weight (LBW) children are not given BCG at birth in Guinea-Bissau; we conducted a randomized trial of BCG at birth (early BCG) vs delayed BCG. METHODS In the period 2004-2008 we recruited 2320 LBW children in Bissau. The children were(More)
OBJECTIVE To investigate the effect of vitamin A supplementation and BCG vaccination at birth in low birthweight neonates. DESIGN Randomised, placebo controlled, two by two factorial trial. SETTING Bissau, Guinea-Bissau. PARTICIPANTS 1717 low birthweight neonates born at the national hospital. INTERVENTION Neonates who weighed less than 2.5 kg were(More)
BACKGROUND Studies from low-income countries have suggested that diphtheria-tetanus-pertussis (DTP) vaccine provided after Bacille Calmette-Guerin (BCG) vaccination may have a negative effect on female survival. The authors examined the effect of DTP in a cohort of low birthweight (LBW) infants. METHODS 2320 LBW newborns were visited at 2, 6 and 12 months(More)
In der vorliegenden Untersuchung wurde die Hirndurchblutung simultan sowohl mit der intravenösen 133 Xenon-Clearancetechnik als auch mit der Kety-Schmidt-Technik gemessen. Unter Standardanästhesiebedingungen wurden Hirndurchblutung, zerebraler Stoffwechsel und die CO 2 -Reaktivität der Hirndurchblutung miteinander verglichen. Untersucht wurden 13 männliche(More)
Whether neonatal vitamin A supplementation (NVAS) should be policy in areas with vitamin A deficiency is debated. We observed that a smaller dose of vitamin A may decrease mortality more than a larger dose and conducted a randomized, double-blind, placebo-controlled trial in Guinea-Bissau with the primary aim of comparing the effect of 50,000 with 25,000 IU(More)
UNLABELLED In this study cerebral blood flow (CBF) was simultaneously measured with the Kety-Schmidt method and the intravenous 133Xe clearance technique. CBF, cerebral metabolic rate of oxygen (CMRO2), and CO2 reactivity of CBF were compared under fentanyl-midazolam anaesthesia and varying paCO2 levels. METHODS Thirteen male patients were studied before(More)
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