Karen P.Y. Lai

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Neural stem cells exist in the developing and adult nervous systems of all mammals, but the basic mechanisms that control their behavior are not yet well understood. Here, we investigated the role of Sonic hedgehog (Shh), a factor vital for neural development, in regulating adult hippocampal neural stem cells. We found high expression of the Shh receptor(More)
Sonic hedgehog (Shh) controls critical cellular decisions between distinct fates in many systems, particularly in stem cells. The Shh network functions as a genetic switch, and we have theoretically and computationally analyzed how its structure can endow it with the ability to switch fate choices at a threshold Shh concentration. The network is composed of(More)
This paper examines knowledge production networks in the fund management industry. Focusing on Asian emerging markets (EMs), I explore how fund managers, brokers and research analysts utilise a combination of texts, analytical structures, codified procedures, and social networks to generate interpretations and perspectives on Asian EMs. Utilising a(More)
In the last decade or so, human geographers have paid greater attention to the significance of discourses. We acknowledge the importance of discursive constructions and metaphorical representations of economic space, and extend the argument by examining the practices that may follow from such discourses. With use of empirical data from a firm-level survey(More)
The current economic crisis casts a shadow over this engaging edited volume which provides a multi-dimensional set of accounts of the contemporary economic geography of the UK. Through the 16 chapters and two contributions by the editors which introduce and conclude the collection, readers are offered a series of thematic windows that can be read in order(More)
We examined differences in regional brain activation during tests of executive function in individuals with Hoarding Disorder (HD), Obsessive Compulsive Disorder (OCD), and healthy controls (HC) using functional magnetic resonance imaging (fMRI). Participants completed computerized versions of the Stroop and Go/No-Go task. We found that during the conflict(More)
OBJECTIVE School-based health centers (SBHCs) reduce access barriers to mental health care and improve educational outcomes for youths. This qualitative study evaluated the innovations and challenges of a unique network of SBHCs in a large, urban school district as the centers attempted to integrate health, mental health, and educational services. METHODS(More)
Motivated by recent research on the dividend irrelevance assumption and research on the importance of political institutions in international financial markets, this cross country study examines whether political institutions affect the substitution effect between stock market liquidity and firm’s dividend policy. Using a sample of 52 countries, we show(More)
Textured surfaces obtained by UV laser ablation of poly(ethylene terephthalate) films were used to study the effect of shape and spacing of surface features on cellular response. Two distinct patterns, cones and ripples with spacing from 2 to 25 μm, were produced. Surface features with different shapes and spacings were produced by varying pulse repetition(More)
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