Karen Nguyen

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A goal of the Chromosome-centric Human Proteome Project is to identify all human protein species. With 3844 proteins annotated as "missing", this is challenging. Moreover, proteolytic processing generates new protein species with characteristic neo-N termini that are frequently accompanied by altered half-lives, function, interactions, and location.(More)
We investigated the role of morph-based differences in the expression of inbreeding depression in loss of the mid-styled morph from populations of tristylous Oxalis alpina. The extent of self-compatibility (SC) of reproductive morphs, the degree of self-fertilization, and the magnitude of inbreeding depression were investigated in three populations of O.(More)
the second quarter of 2013 include initial Phase III results for SAR302503 in myelofibrosis and first data from the Phase III rheumatoid arthritis programme for fostamatinib. A decision from the US Food and Drug Administration (FDA) is also expected in June for two melanoma compounds developed by GlaxoSmithKline: dabrafenib and trametinib. The establishment(More)
BACKGROUND In Ontario, we identified that few hospitals have developed multi-disciplinary case conferences or forums for discussion of patients with palliative care issues. OBJECTIVE We describe the process of creating a province-wide standards document for palliative care Multidisciplinary Case Conferences (pMCCs). DESIGN and setting: A provincial(More)
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