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BACKGROUND Internet-based cognitive behavioural therapy (iCBT) for depression is effective when guided by a clinician, less so if unguided. QUESTION Would guidance from a technician be as effective as guidance from a clinician? METHOD Randomized controlled non-inferiority trial comparing three groups: Clinician-assisted vs. technician-assisted vs.(More)
BACKGROUND Internet-based cognitive behavioural therapy (iCBT) for generalized anxiety disorder (GAD) has been shown to be effective when guided by a clinician. The present study sought to replicate this finding, and determine whether support from a technician is as effective as guidance from a clinician. METHOD Randomized controlled non-inferiority trial(More)
BACKGROUND The gold standard clinical trial design is the double-blind, randomized, controlled trial. No standard practice exists for the "unblinding" of trial participants and no legal obligation is placed on investigators to inform participants of their treatment allocation or study results at the end of a trial. Here we document our experiences of(More)
AIMS To evaluate the outcome of Scottish children with extra hepatic biliary atresia (EHBA) since rationalisation of Kasai services to three English centres in 2002 (The 'Group A' centres). METHODS All Scottish children with EHBA diagnosed between 2002 and 2009 were identified via the Scottish Society of Paediatric Gastroenterology, Hepatology and(More)
BACKGROUND/OBJECTIVES In the era of modern multidisciplinary clinical management, very little is known about the prevalence and presentation of malnutrition in children with gastrointestinal disorders (GastroD) particularly employing composite, global measures of nutritional status. SUBJECTS/METHODS Anthropometry, body composition, dietary intake, eating(More)
BACKGROUND More than 66% of adults in United States are overweight or obese. OBJECTIVE To decrease gastric emptying and cause early and prolonged satiety by endoscopically narrowing the gastric pylorus. DESIGN Thirteen dogs were randomized into 3 groups (suture, sham, and control). SETTING Animal facility. INTERVENTIONS Sutures were placed across(More)
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