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  • Mark D. Wittman, Joan M. Carboni, +30 authors Dolatrai M. Vyas
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2005 (First Publication: 1 September 2005)
  • Compound 3 (BMS-536924), a novel small-molecule inhibitor of the insulin-like growth factor receptor kinase with equal potency against the insulin receptor is described. The in vitro and in vivoExpand
  • Upender Velaparthi, Mark D. Wittman, +15 authors Dolatrai M. Vyas
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 2007 (First Publication: 1 April 2007)
  • The discovery and synthesis of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-one inhibitors of insulin-like growth factor 1-receptor (IGF-1R) are presented. Installing amine containing side chains at theExpand
  • Mark G. Saulnier, Balu N. Balasubramanian, +21 authors Dolatrai M. Vyas
  • Chemistry, Medicine
  • Journal of medicinal chemistry
  • 2005 (First Publication: 1 April 2005)
  • A series of fluoroglycosylated fluoroindolocarbazoles was examined with respect to their topoisomerase I activity, cytotoxicity, and selectivity. The lead clinical candidate from this series,Expand
  • Balu N. Balasubramanian, Denis R. St. Laurent, +21 authors Dolatrai M. Vyas
  • Chemistry
  • 2004 (First Publication: 1 March 2004)
  • A series of fluoroindolocarbazoles were studied with respect to their topoisomerase I activity, cytotoxicity, selectivity, and in vivo antitumor activity. Emerging from this series was BMS-251873, aExpand