Karen M. Mann

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  • Amanda M. Goh, Yuezhen Xue, Marc Leushacke, Ling Li, Julin S. Wong, Poh Cheang Chiam +7 others
  • 2015
The tumour suppressor p53 is regulated primarily at the protein level. In normal tissues its levels are maintained at a very low level by the action of specific E3 ligases and the ubiquitin proteosome pathway. The mutant p53 protein contributes to transformation, metastasis and drug resistance. High levels of mutant p53 can be found in tumours and the(More)
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