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PURPOSE To evaluate the feasibility of breast computed tomography (CT) in terms of radiation dose and image quality. MATERIALS AND METHODS Validated Monte Carlo simulation techniques were used to estimate the average glandular dose (AGD). The calculated photon fluence at the detector for high-quality abdominal CT (120 kVp, 300 mAs, 5-mm section thickness)(More)
Imaging systems are most effective for detection and classification when they exploit contrast mechanisms specific to particular disease processes. A common example is mammography, where the contrast depends on local changes in cell density and the presence of microcalcifications. Unfortunately the specificity for classifying malignant breast disease is(More)
PURPOSE To prospectively and intraindividually compare dedicated breast computed tomographic (CT) images with screen-film mammograms. MATERIALS AND METHODS All patient studies were performed according to protocols approved by the institutional review board and Radiation Use Committee; informed consent was obtained. A breast CT scanner prototype was used(More)
Despite the success of screening mammography contributing to the reduction of cancer mortality, a number of other imaging techniques are being studied for breast cancer screening. In our laboratory, a dedicated breast computed tomography (CT) system has been developed and is currently undergoing patient testing. The breast CT system is capable of scanning(More)
PURPOSE To quantify contrast material enhancement of breast lesions scanned with dedicated breast computed tomography (CT) and to compare their conspicuity with that at unenhanced breast CT and mammography. MATERIALS AND METHODS Approval of the institutional review board and the Radiation Use Committee and written informed consent were obtained for this(More)
PURPOSE To analyze the cost-effectiveness of needle core biopsy (NCB) in a breast cancer screening program. MATERIALS AND METHODS A computer model was used to compare two hypothetical groups of women: those who undergo annual mammographic screening and those observed without screening. All clinically significant outcomes for each group were included in(More)
OBJECTIVE The stress experienced by women undergoing surveillance mammography for benign lesions was compared with that experienced by women undergoing core biopsy of benign lesions. MATERIALS AND METHODS A retrospective survey was mailed to women in whom were diagnosed breast abnormalities that were likely to be benign and that were stable at(More)
PURPOSE To evaluate the cost-effectiveness of screening mammography in women 40-49 years old. MATERIALS AND METHODS A Markov model compared two hypothetical groups; one underwent screening mammography and the other, observation without mammography. Variables tested included frequency of mammography, reduction in breast cancer mortality, and(More)
Monte Carlo procedures using the SIERRA code (validated in a companion article) were used to investigate the scatter properties in mammography. The scatter to primary ratio (SPR) was used for quantifying scatter levels as a function of beam spectrum, position in the field, air gap, breast thickness, tissue composition, and the area of the field of view(More)