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Free radical scavengers, catalase and superoxide dismutase provide protection from oxalate-associated injury to LLC-PK1 and MDCK cells.
PURPOSE Current studies have provided evidence that exposure of renal epithelial cells to oxalate and calcium oxalate crystals induces lipid peroxidation and injures the cells. SinceExpand
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Modeling of hyperoxaluric calcium oxalate nephrolithiasis: experimental induction of hyperoxaluria by hydroxy-L-proline.
A number of animal models have been developed to investigate calcium oxalate (CaOx) nephrolithiasis. Ethylene glycol (EG)-induced hyperoxaluria in rats is most common, but is criticized because EGExpand
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Crystal-cell interaction and apoptosis in oxalate-associated injury of renal epithelial cells.
Two renal epithelial cell lines, LLC-PK1 and Madin-Darby canine kidney (MDCK), were grown in monolayers and exposed to oxalate (Ox) and/or calcium oxalate (CaOx) crystals to investigate cellularExpand
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Calcium phosphate-induced renal epithelial injury and stone formation: involvement of reactive oxygen species.
BACKGROUND Crystal formation and retention are critical events for the formation of kidney stones. Oxalate and calcium oxalate (CaOx) crystals are injurious to renal epithelium, and membranes ofExpand
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Dietary oxalate and calcium oxalate nephrolithiasis.
PURPOSE Patients with calcium oxalate kidney stones are advised to decrease the consumption of foods that contain oxalate. We hypothesized that a cutback in dietary oxalate would lead to a decreaseExpand
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Temporal changes in mRNA expression for bikunin in the kidneys of rats during calcium oxalate nephrolithiasis.
  • S. Iida, A. Peck, +4 authors S. Khan
  • Biology, Medicine
  • Journal of the American Society of Nephrology…
  • 1 May 1999
Inter-alpha-inhibitor and other bikunin-containing proteins are synthesized in relatively large quantities by the liver. These proteins function as Kunitz-type serine protease inhibitors and appearExpand
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Apatite induced renal epithelial injury: insight into the pathogenesis of kidney stones.
PURPOSE Kidney stone formation is associated with the deposition of hydroxyapatite as subepithelial plaques or tubular deposits in the renal papillae. We investigated the effect of renal epithelialExpand
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The effect of calcium on calcium oxalate monohydrate crystal-induced renal epithelial injury
Since hypercalciuria is a common feature of idiopathic calcium oxalate (CaOx) nephrolithiasis, renal epithelial cells of stone patients are exposed to various crystals in the presence of highExpand
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Citrate provides protection against oxalate and calcium oxalate crystal induced oxidative damage to renal epithelium.
PURPOSE Oxalate and calcium oxalate (CaOx) crystals are injurious to renal epithelial cells. The injury is caused by the production of reactive oxygen species (ROS). Citrate is a well-known inhibitorExpand
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Expression of bikunin mRNA in renal epithelial cells after oxalate exposure.
PURPOSE To determine the changes in expression of bikunin in renal epithelial cells on exposure to oxalate and calcium oxalate crystals. MATERIALS AND METHODS This study used reverse transcriptionExpand
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