Karen J. Chan

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CONTEXT Current recommendations for initiation of antiretroviral therapy in patients infected with human immunodeficiency virus type 1 (HIV) are based on CD4 T-lymphocyte cell counts and plasma HIV RNA levels. The relative prognostic value of each marker following initiation of therapy has not been fully characterized. OBJECTIVE To describe rates of(More)
Acute Respiratory Distress Syndrome (ARDS) is characterized by lung injury and hypoxemia, has a high mortality rate, and is associated with significant morbidity including cognitive and emotional sequelae and decreased quality of life. There is limited information regarding which of these factors are associated with decreased quality of life. This study(More)
INTRODUCTION Myocarditis is rarely reported as an extra-pulmonary manifestation of influenza while pregnancy is a rare cause of cardiomyopathy. Pregnancy was identified as a major risk factor for increased mortality and morbidity due to H1N1 influenza in the pandemic of 2009 to 2010. However, to the best of our knowledge there are no previous reports in the(More)
We evaluated changes in rates of new HIV diagnoses in Canada. Our analyses were based on Health Canada data obtained for the period 1995 to 2011. British Columbia, of all Canadian jurisdictions, has had the largest decline in the rate of HIV new diagnoses and in lifetime costs averted over the study period. Highly active antiretroviral therapy (HAART) has(More)
Background Information: Limited research has suggested that rural residents are at increased risk of dementia. Objective: The objective of this study is to determine if rural residence is associated with dementia using both cross-sectional and prospective analyses. Methods: In 1991, 1763 community-dwelling adults aged 65+ participated in the Manitoba Study(More)
OBJECTIVE The objective of the study was to determine the effect of dental health status, dental anxiety and oral-health-related quality of life (OHRQoL) upon homeless people's experience of depression. METHODS A cross-sectional survey was conducted on a sample of homeless people in seven National Health Service Boards in Scotland. All participants(More)
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