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OBJECTIVE To compare the bactericidal properties of povidone-iodine versus alcohol-based chlorhexidine solution for cleansing the gravid abdomen prior to amniocentesis. METHODS Fifty study participants were recruited from the University of Texas Women's Clinic in Houston, Texas. Two baseline swabs of the patients' abdomens were obtained to assess(More)
OBJECTIVE The objective of the study was to examine whether the size of silicon nanovectors (SNVs) inhibits their entrance into the fetal circulation. STUDY DESIGN Pregnant rats were intravenously administered with SNVs or saline. The SNVs were spherical particles with 3 escalating diameters: 519 nm, 834 nm, and 1000 nm. The maternal and fetal(More)
The objectives of this study were to determine (1) the rate of bacterial isolation from the abdomen of women having obstetric ultrasonography, (2) the rate of bacterial transmission to the transducer head, and (3) the eradication rate after routine wiping of the transducer head. A total of 191 obstetric patients participated in this study. At the start of(More)
OBJECTIVE A key event in the pathways leading to preterm labor may be the activation of nuclear factor-kappaB (NF-kappaB) in the fetal membranes and the cervix. Anti-inflammatory agents, such as the corticosteroids, inhibit the activation of NF-kappaB. We proposed to investigate the effects of progesterone pretreatment on cytokine-stimulated activation of(More)
OBJECTIVE Our purpose was to compare the rate of adverse pregnancy outcome in pregnant mice with lower genital tract chlamydial infection who had a prior short chlamydial infection versus a prior long-term infection. STUDY DESIGN A total of 127 female mice were divided into short-term and long-term infection groups. We infected the lower genital tracts(More)
Correlation of the Gram stains prior to and after rupture of the membranes (ROM) and the efficacy of Gram-stain diagnosis for bacterial vaginosis (BV) after membrane rupture has not previously been evaluated. From April 1997 to May 1998, women presenting in labor or for labor induction were invited to participate. Women with ROM prior to hospital(More)
OBJECTIVE The objective of this study was to observe pregnancy outcomes in mice infected transvaginally with Chlamydia trachomatis. METHODS Pregnant mice were inoculated transvaginally with either C. trachomatis (CT) or sterile calf serum (CON) on pregnancy day 4. Pregnancy outcomes as well as genital tract histology and culture were compared. Statistical(More)
OBJECTIVE To compare wet smear and Gram stain diagnoses of bacterial vaginosis among asymptomatic pregnant women. METHODS Between November 1, 1996 and December 31, 1997, asymptomatic women who initiated prenatal care in our obstetric clinics were invited to participate. Exclusion criteria included antimicrobial use within 2 weeks, cervical cerclage,(More)
OBJECTIVE Ten percent povidone-iodine (PVI) is commonly used as a bactericidal solution before amniocentesis is performed. Warming PVI may increase patient comfort; however, the effect of warming on its bactericidal properties is not known. The objective of this study was to determine the effect of warming 10% PVI on its bactericidal properties. STUDY(More)
Cocaine use during pregnancy is associated with increased risk of sexually transmitted diseases, including syphilis and HIV. Many sociological and economic factors related to cocaine use have been shown to contribute to this increased risk. Cocaine may also affect immunological function thereby increasing risk for sexually transmitted diseases. The(More)