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A common feature shared between several human cancer-associated viruses, such as Epstein-Barr virus, Hepatitis B virus and Hepatitis C virus, and Human papillomavirus (HPV) is the ability to reduce the expression of cellular E-cadherin. Since E-cadherin is used by Langerhans cells to move through the stratified epithelium, its reduction may affect the(More)
Methylnaltrexone, a peripherally acting mu-opioid receptor antagonist with restricted ability to cross the blood-brain barrier, reverses opioid-induced constipation (OIC) without affecting analgesia. A double-blind study in patients with advanced illness and OIC demonstrated that methylnaltrexone significantly induced laxation within four hours after the(More)
In a previous formative evaluation of the PACT Geometry tutor, we found significant learning gains, but also some evidence of shallow learning. We hypothesized that a cognitive tutor may be even more effective if it requires students to provide explanations for their solution steps. We hypothesized that this would help students to learn with deeper(More)
In this paper, we describe the ability of evaluators with limited experience to use Heuristic Evaluation (HE) in assessing a complex interface. We analyze our results in terms of the proportion of problems found by different sets of evaluators in different areas of the interface. Our results illustrate that the 5-10 evaluator size advocated by Nielsen and(More)
Contextual Inquiry is a method developed by Beyer and Holtzblatt for grounding design in the context of the work being performed. In this paper, we describe how we adapted the method successfully to perform analyses of pre-existing videotaped presentations. Our goal was to find improvements for a slide presentation program currently in development, called(More)
Contextual Inquiry is a method developed by Beyer and Holtzblatt for grounding design in the context of the work being performed. In this paper, we describe our adaptation of the method to analyze videotaped presentations. Our goal was to find improvements for a slide presentation program currently in development, called 'SlideShow Commander.' Contextual(More)
As traditional media make the transition to the web, the need for a systematic way of assessing the entertainment value of interfaces becomes increasingly important. In this paper we describe an experiment using online manipulations of traditional paper comic books to a) evaluate the effectiveness of different online presentations of a traditional(More)
Flexor digitorum profundus (FDP) tendon avulsion is a common injury in sports. This is secondary to forced extension against flexor digitorum profundus contraction. However, avulsion injury of the FDP tendon secondary to an enchondroma of the distal phalanx is extremely rare. There have only been three previous reports of such an occurrence. This report(More)
We developed a 2D multi-agent stochastic model of interaction between cellular debris, bacteria and neutrophils in the surface cutaneous wound with local hypoxia. Bacteria, which grow logistically with a maximum carrying capacity, and debris are phagocytosed by neutrophils with probability determined by the partial pressure of oxygen in the tissue, pO 2  =(More)