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DNA breaks and chromosome pulverization from errors in mitosis
The involvement of whole-chromosome aneuploidy in tumorigenesis is the subject of debate, in large part because of the lack of insight into underlying mechanisms. Here we identify a mechanism byExpand
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DNA replication checkpoint prevents precocious chromosome segregation by regulating spindle behavior.
The DNA replication checkpoint maintains replication fork integrity and prevents chromosome segregation during replication stresses. Mec1 and Rad53 (human ATM/ATR- and Chk2-like kinases,Expand
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Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle
Separation of duplicated centrosomes (spindle-pole bodies or SPBs in yeast) is a crucial step in the biogenesis of the mitotic spindle. In vertebrates, centrosome separation requires the BimC familyExpand
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Lipid accumulation facilitates mitotic slippage-induced adaptation to anti-mitotic drug treatment
Aberrant lipid accumulation is a hallmark of cancer known to contribute to its aggressiveness and malignancy. Emerging studies have demonstrated context-dependent changes in lipid metabolism duringExpand
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50 years on … the discovery of tubulin continues to advance cancer treatment.
Abstract 3454: Autophagy governs tumorigenic effects following mitotic slippage
Antimitotic drugs are often administered as first‐line chemotherapy in several malignancies. However, their clinical success is often limited by acquired chemoresistance and disease relapse. TheExpand
Abstract C72: A mechanistic link between whole‐chromosome aneuploidy and DNA damage
Cancer is associated with aneuploidy— both structural defects in chromosomes and abnormal numbers of intact chromosomes. The contribution of chromosome breaks to tumorigenesis is well acceptedExpand
Abstract B59: Autophagy mediates senescence and supports survival upon treatment with anti-mitotic drugs
Anti-mitotic drugs such as paclitaxel and vinblastine have been used as front-line therapies for the treatment of many cancers. These agents induce activation of a spindle assembly checkpoint (SAC),Expand