BACKGROUND The forkhead transcription factor Foxo3 is a master regulator and potent suppressor of primordial follicle activation. Loss of Foxo3 function in the mouse leads to premature ovarian failure (POF) due to global follicle activation. METHODS AND RESULTS Here, we show that the mouse Foxo3 locus is haploinsufficient, and that Foxo3-/+ females… (More)
The hereditary spastic paraplegias (HSPs) are a genetically heterogeneous group of disorders characterised by progressive corticospinal tract degeneration and the development of lower limb spasticity [1, 2]. Autoso-mal-dominant HSP is the most commonly inherited form of the disease and in this group, SPG4 mutations account for *40 % of cases . The SPG4… (More)
JAMI (Java-based Agglutination of Medical Information) is designed as a framework for integrating heterogeneous information systems used in healthcare related institutions. It is one of the implementations under the W3-EMRS project 1 aimed at using the World Wide Web (Web) to unify different hospital information systems. JAMI inherited several design… (More)
It is commonplace for students to enter university with skills deficiencies. However, this is cause for growing concern in the context of South Africa, as these `deficient' students are becoming more numerous. Public secondary schools in South Africa are failing to create students with adequate skills for careers in the STEM fields. This paper isolates… (More)
The feature-level, unlike the match score-level, lacks multi-modal fusion guidelines. This work demonstrates a practical approach for improved image-based biometric feature-fusion. The approach extracts and combines the face, fingerprint and palmprint at the feature-level for improved human identification accuracy. Feature-fusion guidelines, proposed in… (More)
There is unfortunately a mistake in the protein notation for one of the SPG4 mutations in Table 1. The c.1253_1255 delAAG mutation was identified in Patient 5. The amino acid change resulting from this deletion is p.Glu418del, not p.E418fsX198. The correct table is given in the following page.
Modelling tools are widely used by national parks, both within South Africa and in countries around the world. The modelling of animal behaviour, particularly in South Africa and other African countries, is well established. These models, however, tend to be developed with one particular application and species in mind and are not reusable in other… (More)
In this paper, the implementation of a veterinary expert system which allows for remote access through a mobile phone is examined. The background to the problem, including the circumstances the system would be used in, is discussed and the dierent tools available to assist in developing an expert system are examined. The process of acquiring the knowledge… (More)