Karen A. Donato

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A cluster of risk factors for cardiovascular disease and type 2 diabetes mellitus, which occur together more often than by chance alone, have become known as the metabolic syndrome. The risk factors include raised blood pressure, dyslipidemia (raised triglycerides and lowered high-density lipoprotein cholesterol), raised fasting glucose, and central(More)
The metabolic syndrome has received increased attention in the past few years. This statement from the American Heart Association (AHA) and the National Heart, Lung, and Blood Institute (NHLBI) is intended to provide up-to-date guidance for professionals on the diagnosis and management of the metabolic syndrome in adults. The metabolic syndrome is a(More)
(Circulation. 2014;129[suppl 2]:S102-S138) © 2013 the expert Panel Members. Circulation is published on behalf of the American heart Association, Inc., by Wolters Kluwer; the Journal of the American College of Cardiology is published on behalf of the American College of Cardiology Foundation by elsevier Inc.; Obesity is published on behalf of the obesity(More)
OBJECTIVE To describe and evaluate relationships between body mass index (BMI) and blood pressure, cholesterol, high-density lipoprotein-cholesterol (HDL-C), and hypertension and dyslipidemia. RESEARCH METHODS AND PROCEDURES A national survey of adults in the United States that included measurement of height, weight, blood pressure, and lipids (National(More)
s of 2,160 publications were screened against the I/E criteria independently by 2 reviewers (i.e., independent contractors) which resulted in 1,776 publications being excluded and 384 publications being Downloaded From: http://content.onlinejacc.org/ by Adrienne Avilez on 11/12/2013 M AN US CR IP T AC CE PT ED ACCEPTED MANUSCRIPT Jensen MD, et al. 2013(More)
In recent years, researchers have turned to transient gene expression (TGE) as an alternative to CHO stable cell line generation for early-stage antibody development. Despite advances in transfection methods and culture optimization, the majority of CHO-based TGE systems produce insufficient antibody titers for extensive use within biotherapeutic(More)
OBJECTIVE To provide insight into discussions at the Surgeon General's Listening Session, "Toward a National Action Plan on Overweight and Obesity," and to complement The Surgeon General's Call to Action to Prevent and Decrease Overweight and Obesity. RESEARCH METHODS AND PROCEDURES On December 7 and 8, 2000, representatives from federal, state, academic,(More)
Global Perspective The prevalence, or epidemic, of obesity is increasing in most countries throughout the world. The issues for addressing both its prevention and treatment will differ from one country to another, according to the stage of the epidemic, cultural and economic circumstances, and the commitment of the public and politicians. In some(More)
Cross-sectional surveys of the civilian noninstitutionalized population of the United States, including in-home interviews and clinical examinations, were employed to examine trends in consumption of energy and fat, prevalence of overweight in the population, the association of overweight with levels of blood pressure and blood cholesterol, and the(More)
The national education programs and campaigns described here are examples of the many unique kinds of federal efforts under way to promote the pillars of healthy eating and increased physical activity included in the "Healthier US Initiative." They are similar in that: 1) they are based on the best available science that a health problem exists, and 2) that(More)