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—We describe the design of Kaldi, a free, open-source toolkit for speech recognition research. Kaldi provides a speech recognition system based on finite-state transducers (using the freely available OpenFst), together with detailed documentation and scripts for building complete recognition systems. Kaldi is written is C++, and the core library supports(More)
In early 2013, the new classification of tumours of soft tissue and bones was released. This edition belongs to the fourth series of so-called Blue Books published under the auspices of the World Health Organisation (WHO). The current classification follows the previous third edition, from which it differs in several aspects. The vast majority of changes(More)
Sequence-discriminative training of deep neural networks (DNNs) is investigated on a 300 hour American English conversational telephone speech task. Different sequence-discriminative criteria — maximum mutual information (MMI), minimum phone error (MPE), state-level minimum Bayes risk (sMBR), and boosted MMI — are compared. Two different heuristics are(More)
We describe a lattice generation method that is exact, i.e. it satisfies all the natural properties we would want from a lattice of alternative transcriptions of an utterance. This method does not introduce substantial overhead above one-best decoding. Our method is most directly applicable when using WFST decoders where the WFST is “fully(More)
In this paper, we investigate alternative ways of processing MFCC-based features to use as the input to Deep Neural Networks (DNNs). Our baseline is a conventional feature pipeline that involves splicing the 13-dimensional front-end MFCCs across 9 frames, followed by applying LDA to reduce the dimension to 40 and then further decorrelation using MLLT.(More)
This paper describes the speech activity detection (SAD) system developed by the Patrol team for the first phase of the DARPA RATS (Robust Automatic Transcription of Speech) program, which seeks to advance state of the art detection capabilities on audio from highly degraded communication channels. We present two approaches to SAD, one based on Gaussian(More)
BACKGROUND Epidermolysis bullosa simplex (EBS) is an inherited skin disorder caused by mutations in the keratin 5 (KRT5) and keratin 14 (KRT14) genes, with fragility of basal keratinocytes leading to epidermal cytolysis and blistering. OBJECTIVES In this study, we characterized mutations in KRT5 and KRT14 genes in patients with EBS and investigated their(More)
Nestin was originally identified as a class VI intermediate filament protein that is expressed in stem cells and progenitor cells in the mammalian CNS during development. This protein is replaced in the adult organism by other intermediate filament proteins; however, nestin may be re-expressed under certain pathological conditions such as ischemia,(More)