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- Daniel L. Worthley, Michael Churchill, +48 authors Timothy C Wang
- Cell
- 2015
The stem cells that maintain and repair the postnatal skeleton remain undefined. One model suggests that perisinusoidal mesenchymal stem cells (MSCs) give rise to osteoblasts, chondrocytes, marrow… (More)
- Yoku Hayakawa, Hiroshi Ariyama, +27 authors Timothy C Wang
- Cancer cell
- 2015
The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in the gastric corpus isthmus. Mist1(+) stem… (More)
- Yoku Hayakawa, Kosuke Sakitani, +24 authors Timothy C Wang
- Cancer cell
- 2017
Within the gastrointestinal stem cell niche, nerves help to regulate both normal and neoplastic stem cell dynamics. Here, we reveal the mechanisms underlying the cancer-nerve partnership. We find… (More)
- Bernhard W. Renz, Ryota Takahashi, +27 authors Timothy C. Wang
- Cancer cell
- 2018
Catecholamines stimulate epithelial proliferation, but the role of sympathetic nerve signaling in pancreatic ductal adenocarcinoma (PDAC) is poorly understood. Catecholamines promoted ADRB2-dependent… (More)
- Xiaowei Chen, Huan Deng, +32 authors Timothy C Wang
- Cell stem cell
- 2017
Myeloid-biased hematopoietic stem cells (MB-HSCs) play critical roles in recovery from injury, but little is known about how they are regulated within the bone marrow niche. Here we describe an… (More)
- Bernhard W Renz, Takayuki Tanaka, +22 authors Timothy C Wang
- Cancer discovery
- 2018
In many solid tumors, parasympathetic input is provided by the vagus nerve, which has been shown to modulate tumor growth. However, whether cholinergic signaling directly regulates progression of… (More)
- Zina Dubeykovskaya, Yiling Si, +16 authors Timothy C Wang
- Nature communications
- 2016
CD11b(+)Gr-1(+) myeloid-derived suppressor cells (MDSCs) expand in the spleen during cancer and promote progression through suppression of cytotoxic T cells. An anti-inflammatory reflex arc involving… (More)
- Yoku Hayakawa, Hiroshi Ariyama, +30 authors Timothy C Wang
- 2015
- Xiaowei Chen, Michael J. Churchill, +11 authors Timothy C Wang
- Oncotarget
- 2015
Food allergy can influence the development of colorectal cancer, although the underlying mechanisms are unclear. While mast cells (MC) store and secrete histamine, immature myeloid cells (IMC) are… (More)
- Xiaowei Chen, Yoshihiro Takemoto, +9 authors Timothy C Wang
- Oncoimmunology
- 2017
The colorectal tumor microenvironment contains a diverse population of myeloid cells that are recruited and converted to immunosuppressive cells, thus facilitating tumor escape from immunoediting. We… (More)