Karabi Ghose

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In a double-blind crossover study, 8 patients with classical migraine received disulfiram (400 mg/day) for 6 days, alternating with matched placebo tablets at 2 weekly intervals. Intravenous dopamine and tyramine pressor tests were performed on the 3rd and 6th days of each phase, respectively. 50-75% of patients experienced migraine attacks within 24 h of a(More)
AIMS Cystitis, a rare adverse effect of systematically administered drugs, was first reported to be associated with a nonsteroidal antiinflammatory drug, tiaprofenic acid, in 1991. Similar reports of adverse effect of tiaprofenic acid were received by a number of national drug monitoring centres. It was therefore decided to investigate the frequency of(More)
FG4963 a phenylpiperidine derivative and potent 5-HT reuptake inhibitor at neuronal sites was investigated in a group of 10 depressive patients, and its effect was compared with that of amitryptyline in a group of 10 depressive patients treated with amitriptyline. FG4963 was found to be significantly inferior as an antidepressant compared to amitryptyline(More)
Forty-one out-patients with a history of at least three attacks of depressive illness were randomly allocated to treatment on a double-blind basis for one year with either mianserin 20 mg three times daily plus placebo lithium tablets, or to lithium tablets once daily plus placebo mianserin tablets. After one year, the dosage of mianserin was increased to(More)
The tyramine-dose/pressor response test was carried out on a series of patients suffering from primary depressive illness before and during treatment with amitriptyline. The severity of their depression was assessed during the study by the Hamilton Rating Scale (HRS). The decreased tyramine sensitivity induced by the drug, which is related to the inhibition(More)
The antidepressant activities of mianserin hydrochloride were investigated and compared with those of amitriptyline. The therapeutic efficacy of the two drugs appeared similar, but the incidence of side-effects was significantly higher with amitriptyline. Plasma levels of mianserin were determined during the trial and were not related to the therapeutic(More)
  • Karabi Ghose
  • Methods and findings in experimental and clinical…
  • 1984
Tyramine, an indirectly acting sympathomimetic amine, can be used as a pharmacological tool to assess the peripheral adrenergic activity and its interactions with drugs in man. Of the various techniques used, the tyramine pressor test appears to be the most reliable method. It is convenient to perform and carries no significant morbidity, provided the(More)
A 39-year-old female patient who had been receiving 30 mg of baclofen daily for 5 months was admitted to the hospital about 12 hr after overdose of this drug (450 mg). On admission, she was comatose, flaccid, and in respiratory failure. Later she developed muscle twitchings and had several epileptic fits. She was treated symptomatically and became conscious(More)
Tyramine, noradrenaline and phenylephrine pressor response tests were performed in patients suffering from affective disorders during various drug therapies or following electroconvulsive therapies (ECT). Tricyclic and related antidepressive drugs produced decreased tyramine sensitivity and increased noradrenaline sensitivity as expected from their usual(More)