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BACKGROUND Aberrant beta-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate beta-catenin activity for therapeutic purposes have proven elusive to date. METHODOLOGY To uncover genetic dependencies in breast cancer cells that harbor active beta-catenin signaling, we performed(More)
Background: Aberrant b-catenin signaling plays a key role in several cancer types, notably colon, liver and breast cancer. However approaches to modulate b-catenin activity for therapeutic purposes have proven elusive to date. Methodology: To uncover genetic dependencies in breast cancer cells that harbor active b-catenin signaling, we performed RNAi-based(More)
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