Kara B. Cardwell

Learn More
Dengue viruses (DENV) infect 50 to 100 million people worldwide per year, of which 500,000 develop severe life-threatening disease. This mosquito-borne illness is endemic in most tropical and subtropical countries and has spread significantly over the last decade. While there are several promising vaccine candidates in clinical trials, there are currently(More)
Dengue virus (DENV) is the predominant mosquito-borne viral pathogen that infects humans with an estimated 50 to 100 million infections per year worldwide. Over the past 50 years, the incidence of dengue disease has increased dramatically and the virus is now endemic in more than 100 countries. Moreover, multiple serotypes of DENV are now found in the same(More)
Cantagalo virus (CTGV) is the etiologic agent of a pustular disease in dairy cows and dairy workers in Brazil with important economical and occupational impacts. Nevertheless, no antiviral therapy is currently available. ST-246 is a potent inhibitor of orthopoxvirus egress from cells and has proved its efficacy in cell culture and in animal models. In this(More)
A Novel Benzoxazole Inhibitor of Dengue Virus Replication that 1 Targets the NS3 Helicase 2 3 Chelsea M. Byrd*, Douglas W. Grosenbach, Aklile Berhanu, Dongcheng Dai, 4 Kevin F. Jones, Kara B. Cardwell, Christine Schneider,Guang Yang, 5 Shanthakumar Tyavanagimatt, Chris Harver, Kristin A. Wineinger, Jessica Page, 6 Eric Stavale, Melialani A. Stone, Kathleen(More)
  • 1