Kapil G. Gadkar

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BACKGROUND Recent advances in molecular biology techniques provide an opportunity for developing detailed mathematical models of biological processes. An iterative scheme is introduced for model identification using available system knowledge and experimental measurements. RESULTS The scheme includes a state regulator algorithm that provides estimates of(More)
The application of biosimulation to drug discovery and optimization is enhanced by applying in silico disease models that capture reported heterogeneity in patient clinical phenotypes. Using such a diverse cohort of virtual patients improves the robustness of the in silico analysis and allows critical hypothesis testing to explore key knowledge gaps. The(More)
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